Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating.
Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating.
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DOI：
10.1002/eat.23563
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Bohon C
中科院分区：
文献类型：
--
作者：
Hagan KE;Bohon C
大脑结构的改变与几种形式的精神病理学的发病和急性期有关。然而，缺乏对暴食者大脑结构的研究，导致对暴食相关机制的理解不足。青少年女孩和妇女（14至35岁）与暴食（n = 56）和组年龄匹配的女孩和妇女没有暴食（n = 26）完成结构磁共振成像（MRI）扫描和基于访谈和自我报告的进食障碍和一般精神病理学评估。使用FreeSurfer处理MRI数据。协方差分析测试了暴饮暴食组和非暴饮暴食组之间先验选择的感兴趣区域的皮质下体积和皮质厚度的平均差异，控制了年龄，体重指数，清除频率，抑郁症和药物使用。探索性偏相关测试了暴食参与者大脑结构和饮食失调症状之间的关联。我们没有观察到有和没有暴饮暴食的女孩和妇女在区域皮质下体积和皮质厚度上的差异。在暴饮暴食的参与者中，态度性进食障碍症状的严重程度与尾侧额中回、右侧中央前回、右侧中央后回、上级顶叶、左侧下顶叶厚度和左侧小脑体积呈负相关;然而，这些相关性在多重比较校正后无法生存。态度性进食障碍症状和额顶叶变薄之间的相关性可能代表暴饮暴食的状态标志。未来的研究可能会调查额顶叶变薄是否与疾病持续时间有关，或者在停止暴食后持续存在。
Alterations in brain structure have been implicated in the onset and acute phases of several forms of psychopathology. However, there is a dearth of research investigating brain structure in persons with binge eating, contributing to poor understanding of mechanisms associated with binge eating. Adolescent girls and women (aged 14 to 35 years) with binge eating (n = 56) and group age-matched girls and women without binge eating (n = 26) completed structural magnetic resonance imaging (MRI) scans and interview-based and self-report assessments of eating disorder and general psychopathology. MRI data were processed using FreeSurfer. Analysis of covariance tested mean differences in subcortical volume and cortical thickness of a priori selected regions of interest between binge eating and non-binge-eating groups, controlling for age, body mass index, purging frequency, depression, and medication use. Exploratory partial correlations tested associations between brain structure and eating disorder symptoms within participants with binge eating. We did not observe differences in regional subcortical volume and cortical thickness between girls and women with and without binge eating. Within participants with binge eating, severity of attitudinal eating disorder symptoms was inversely associated with caudal middle frontal gyrus, right precentral gyrus, right postcentral gyrus, superior parietal, left inferior parietal thickness, and left accumbens volume; however, these associations would not survive multiple-comparison corrections. Correlations between attitudinal eating disorder symptoms and frontoparietal thinning may represent a state marker of binge eating. Future research could investigate whether frontoparietal thinning worsens with illness duration or persists beyond binge eating cessation.
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