How many types of calcium channels exist in neurones?
How many types of calcium channels exist in neurones?
复制标题
神经元中存在多少种钙通道？
DOI：
10.1016/0166-2236(85)90023-2
复制
发表时间：
1985
影响因子：
15.9
通讯作者：
Richard J. Miller
中科院分区：
文献类型：
--
作者：
Richard J. Miller
电压敏感性钙通道的生物化学研究取得了一定的成功，但也引起了一些值得注意的问题。最近的电生理学研究为多种神经元钙通道的存在提供了证据。这些不同通道的结构和功能是目前研究的热点。本文比较了来自生物化学和电生理学两方面的数据。电压敏感性钙通道在神经元钙通道中的重要性。平滑肌和心肌中的组织数量，这些通路为肌肉收缩提供钙离子（Ca 2+），而在许多内分泌细胞和神经元中，它们为激素和神经递质的释放提供Ca 2+。目前对这些通道的生物化学和电生理特性的研究揭示了一些奇怪的异常，表明钙通道可能是一个相当异质的组，比较生物化学和电生理数据的任务现在是一项令人着迷的努力。平滑肌中的电压敏感性钙通道对许多药理学试剂敏感。特别是去氢吡啶钙通道阻断剂是最有效的药物，例如mtrendipme，硝苯地平和其它二氢吡啶在约10- 100 μ mol/L的浓度下阻断许多平滑肌中的钙通道。9 M其他类别的有机钙通道阻滞剂包括苯烷基胺类药物，例如维拉帕米和D-600或苯硫氮卓类药物，例如地尔硫卓。这些药物的效力略低于二氢吡啶类药物。此外，在心肌中，有机钙通道阻断剂包括二氢吡喃酮也比在平滑肌中的效力稍低。这似乎是由于最近在几个实验室中描述的药物/通道相互作用的电压依赖性2，3另一个有趣的特征是最近开发的“激动剂”二氢吡啶类，如BAY K8644和CGP 28392（参考文献4- 5）。
Biochemical attempts to Identify voltage sensitive calcium channels have met with some success but have also ratsed mterestlng questions Recent electrophyszologtcal studies have now provided evidence for multiple neuronal calcium channels The dtstrtbutlon and functions of these various channels are now the sublect of mtenstve mvesttgattons This article compares data from both biochemical and electrophystologtcal sourcesVoltage sensitive calcium channels are of critical importance in a number of tissues In smooth and cardiac muscle, these pathways provide calcium ions (Ca 2+) for muscle contraction whereas in a number of endocrine cells and neurones they provide Ca 2+ for the release of hormones and neurotransmitters_ Current research on both the biochemical and electrophyslologlcal properties of these channels has revealed some curious anomalies that suggest that calcium channels may be a fairly heterogeneous group of entities_ The task of comparing the biochemical and electrophyslologlcal data is now a fascinating endeavour Voltage sensitive calcium channels in smooth muscle are sensitive to a number of pharmacological agents In particular the dlhydropyndine calcium channel blockers are the most potent i Drugs such as mtrendipme, nifedtpine and other dihydropyridInes block calcium channels in a number of smooth muscles at concentrations around 10-9 M Other classes of organic calcium channel blockers include phenylalkylamines such as verapamtl and D-600 or benTothlazepines such as diltlazem These agents are somewhat less potent than the dihydropyndines_ Moreover in cardiac muscle, organic calcium channel blockers including dihydropyndxnes are also somewhat less potent than in smooth muscle This appears to be due to the voltage dependence of drug/channel interactions recently described in several laboratories 2, 3 A further interesting feature is the recent development of'agonist'dlhydropyrIdlnes such as BAY K8644 and CGP 28392 (Refs 4-
二氢吡啶结合位点是电压敏感的钙通道吗？
影响因子：
6.1
作者：
Miller,RJ;Freedman,SB
通讯作者：
Freedman,SB
二氢吡啶对培养神经元细胞释放神经递质的影响。
影响因子：
6.1
作者：
Shalaby,IA;Kongsamut,S;Freedman,SB;Miller,RJ
通讯作者：
Miller,RJ
钙拮抗剂 高亲和力结合并抑制克隆细胞系中的钙转运。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Toll,L
通讯作者：
Toll,L