WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients
WDR1 and CLNK gene polymorphisms correlate with serum glucose and high-density lipoprotein levels in Tibetan gout patients
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WDR1和CLNK基因多态性与西藏痛风患者血糖和高密度脂蛋白水平的相关性
DOI：
10.1007/s00296-015-3378-y
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发表时间：
2016-03
影响因子：
4
通讯作者：
Kang, Longli
中科院分区：
文献类型：
--
作者：
Feng, Tian;Liu, Kai;Jin, Tianbo;Kang, Longli
目前的证据表明遗传和代谢综合征有助于痛风的进展。具体而言，WDR 1和CLNK基因可能在欧洲血统人群的痛风进展中发挥作用。然而，没有研究关注中国人群，特别是藏族人。本研究旨在确定这两个基因的变异是否与中国-西藏痛风患者的痛风相关指标相关。在319例汉族藏族痛风患者和318例对照组中检测了WDR 1和CLNK基因11个单核苷酸多态性。我们使用单因素方差分析来评估多态性对痛风的影响，基于空腹静脉血样本中代谢指标的平均血清水平，如白蛋白，葡萄糖（GLU），甘油三酯，胆固醇，高密度脂蛋白（HDL-C），肌酐和尿酸。所有p值均经Bonferroni校正。WDR 1和CLNK基因多态性影响痛风发生的多个危险因素。在WDRI多态性rs 4604059（p = 0.005）和rs 12498927（p = 0.005）的不同基因型组之间检测到血清GLU水平的显著差异。此外，在CLNK多态性rs 2041215的不同基因型组之间检测到血清HDL-C水平的显著差异（p = 0.001）。CLNK的多态性也影响白蛋白、甘油三酯和肌酐水平。本研究首次在中国藏族人群中探讨了WDR 1与CLNK基因多态性之间的正相关关系。本研究结果为遗传多态性对中国藏族人群痛风相关因素的影响提供了重要证据。
Current evidence suggests heredity and metabolic syndrome contributes to gout progression. Specifically, the WDR1 and CLNK genes may play a role in gout progression in European ancestry populations. However, no studies have focused on Chinese populations, especially Tibetan individuals. This study aims to determine whether variations in these two genes correlate with gout-related indices in Chinese-Tibetan gout patients. Eleven single-nucleotide polymorphisms in the WDR1 and CLNK genes were detected in 319 Chinese-Tibetan gout patients and 318 controls. We used one-way analysis of variance to evaluate the polymorphisms' effects on gout based on mean serum levels of metabolism indicators, such as albumin, glucose (GLU), triglycerides, cholesterol, high-density lipoproteins (HDL-C), creatinine, and uric acid, from fasting venous blood samples. All p values were Bonferroni corrected. Polymorphisms of the WDR1 and CLNK genes affected multiple risk factors for gout development. Significant differences in serum GLU levels were detected between different genotypic groups with WDRI polymorphisms rs4604059 (p = 0.005) and rs12498927 (p = 0.005). In addition, significant differences in serum HDL-C levels were detected between different genotypic groups with the CLNK polymorphism rs2041215 (p = 0.001). Polymorphisms of CLNK also affected levels of albumin, triglycerides, and creatinine. This study is the first to investigate and identify positive correlations between WDR1 and CLNK gene polymorphisms in Chinese-Tibetan populations. Our findings provide significant evidence for the effect of genetic polymorphisms on gout-related factors in Chinese-Tibetan populations.
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影响因子：
3.4
作者：
Malik, Aarti;Schumacher, H. Ralph;Clayburne, Gilda M.
通讯作者：
Clayburne, Gilda M.
病例对照样本组中 CLNK 基因和 ZNF518B 基因的遗传变异与痛风相关
影响因子：
4
作者：
Jin, Tian-bo;Ren, Yongchao;Kang, Longli
通讯作者：
Kang, Longli
影响因子：
5.4
作者：
Foggin, Peter M.;Torrance, Marion E.;Torrance, Jane
通讯作者：
Torrance, Jane
DOI：
10.1016/0026-0495(64)90137-4
发表时间：
1964-06
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
J. Padova;A. Patchefsky;G. Onesti;G. Faludi;G. Bendersky
通讯作者：
J. Padova;A. Patchefsky;G. Onesti;G. Faludi;G. Bendersky
影响因子：
30.8
作者：
Thomas, Roman K.;Baker, Alissa C.;Garraway, Levi A.
通讯作者：
Garraway, Levi A.