Immunocytologic findings in a case of Vogt-Koyanagi-Harada syndrome.
Immunocytologic findings in a case of Vogt-Koyanagi-Harada syndrome.
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Vogt-Koyanagi-Harada 综合征病例的免疫细胞学发现。
DOI：
10.1016/s0161-6420(93)31506-x
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发表时间：
1993
期刊：
影响因子：
13.7
通讯作者：
Foos,RY
中科院分区：
文献类型：
--
作者：
Kahn,M;Pepose,JS;Green,WR;Miller,J;Foos,RY
背景：Vogt-Koyanagi-Harada(VKH)综合征是一种慢性全葡萄膜炎，其远期视力往往较差。据作者所知，之前只有两篇报道描述了VKH综合征患者眼部的免疫细胞学结果，都是在疾病的相对晚期进行研究。方法：作者对1例活动期VKH综合征患者的眼球摘除进行免疫细胞学研究，使用抗单个核亚群、主要组织相容性抗原以及病毒和梅毒螺旋体的单抗，以更好地了解疾病的病理生理机制。结果：活动期VKH综合征患者葡萄膜致密渗出物主要由T淋巴细胞和人类白细胞抗原DR+巨噬细胞组成。视网膜内可见散在的T细胞和浆细胞。此外，非树突状CD1(Leu-6)阳性细胞定位于脉络膜，靠近脉络膜黑素细胞。结论：虽然VKH综合征的病因仍然是个谜，但作者的免疫细胞学结果与T细胞介导的疾病相一致。在显示浸润液中的CD1(Leu-6)阳性细胞时，作者提出了这些细胞在VKH综合征的病因学中的潜在作用。
Background:Vogt-Koyanagi-Harada (VKH) syndrome is a form of chronic panuveitis that often has a poor long-term visual outcome. To the authors' knowledge, there have been only two previous reports describing immunocytologic findings in the eyes of patients with VKH syndrome, all studied in relatively late stages of the disease.Methods:The authors performed immunocytologic studies on the enucleated eyes of a patient with active VKH syndrome, using monoclonal antibodies to mononuclear subsets, major histocompatibility antigens, and viral and treponemal agents, to better understand the pathophysiologic mechanisms underlying the disease. Emulsified chorioretinal tissue also was processed for viral isolation in tissue culture and forTreponema pallidumby rabbit inoculation studies.Results:The dense uveal infiltrates in active VKH syndrome are composed predominantly of T lymphocytes and HLA-DR+ macrophages. Scattered T cells and plasma cells were present in the retina. In addition, nondendritic-appearing CD1(Leu-6) positive cells were localized in the choroid, in close proximity to choroidal melanocytes. No microbial agents were identified.Conclusions:Whereas the etiology of the VKH syndrome remains an enigma, the authors' immunocytologic findings are consistent with a T-cell-mediated disorder. In demonstrating CD1 (Leu-6) positive cells in the infiltrates, the authors propose a potential role for these cells in the etiology of VKH syndrome.
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DOI：
--
发表时间：
1986
期刊：
Ophthalmology (Rochester, Minn.)
影响因子：
--
作者：
Chi;R. Nussenblatt;Leslie S. Fujikawa;Alan G. Palestine;Garth Stevens;Leonard M. Parver;Martha W. Luckenbach;Toichiro Kuwabara
通讯作者：
Toichiro Kuwabara
通过 CD1 特异性抗体描绘具有或不具有功能潜力的人类胸腺细胞。
影响因子：
4.4
作者：
A. de la Hera;M. Toribio;C. Martínez
通讯作者：
C. Martínez
Vogt-Koyahagi-Harada 综合征中细胞介导的对人髓磷脂碱性蛋白的免疫。
影响因子：
4.4
作者：
R. Manor;E. Livni;S. Cohen
通讯作者：
S. Cohen
Vogt-小柳-原田病外周血和脑脊液中淋巴细胞亚群的研究
DOI：
--
发表时间：
1985
期刊：
Rinshō shinkeigaku Clinical neurology
影响因子：
--
作者：
N. Kuwasaki;H. Shoji;M. Kaji;K. Matsumoto;M. Yokoyama
通讯作者：
M. Yokoyama
AIDS和ARC患者外周血中CD1阳性细胞增加。
影响因子：
4.4
作者：
S. Chollet;G. Pialoux;M. Gougerot
通讯作者：
M. Gougerot