Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development.
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DOI：
10.1371/journal.pone.0002639
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发表时间：
2008-07-09
期刊：
影响因子：
3.7
通讯作者：
Hodes, Richard J.
中科院分区：
文献类型：
--
作者：
Chiang, Y. Jeffrey;Hsiao, Susan J.;Yver, Dena;Cushman, Samuel W.;Tessarollo, Lino;Smith, Susan;Hodes, Richard J.
Tankyrases are proteins with poly(ADP-ribose) polymerase activity. Human tankyrases post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, and trafficking of glut4-containing vesicles. To date, however, little is known about in vivo functions for tankyrases. We recently reported that body size was significantly reduced in mice deficient for tankyrase 2, but that these mice otherwise appeared developmentally normal. In the present study, we report generation of tankyrase 1-deficient and tankyrase 1 and 2 double-deficient mice, and use of these mutant strains to systematically assess candidate functions of tankyrase 1 and tankyrase 2 in vivo. No defects were observed in development, telomere length maintenance, or cell cycle regulation in tankyrase 1 or tankyrase 2 knockout mice. In contrast to viability and normal development of mice singly deficient in either tankyrase, deficiency in both tankyrase 1 and tankyrase 2 results in embryonic lethality by day 10, indicating that there is substantial redundancy between tankyrase 1 and tankyrase 2, but that tankyrase function is essential for embryonic development.
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DOI：
10.1016/0167-4889(84)90100-9
发表时间：
1984-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
GLIEMANN, J;REES, WD;FOLEY, JA
通讯作者：
FOLEY, JA
影响因子：
11.4
作者：
Canudas, Silvia;Houghtaling, Benjamin R.;Smith, Susan
通讯作者：
Smith, Susan
影响因子：
10.5
作者：
Chang, W;Dynek, JN;Smith, S
通讯作者：
Smith, S
影响因子：
14.9
作者：
Garcia, Christine Kim;Wright, Woodring E;Shay, Jerry W
通讯作者：
Shay, Jerry W
影响因子：
5.3
作者：
Chiang, YJ;Hemann, MT;Hodes, RJ
通讯作者：
Hodes, RJ