Prognostic significance of variability in ambulatory and home blood pressure from the Ohasama study.
Prognostic significance of variability in ambulatory and home blood pressure from the Ohasama study.
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DOI：
10.2188/jea.17.109
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发表时间：
2007-07
影响因子：
4.7
通讯作者：
Ohkubo T
中科院分区：
文献类型：
--
作者：
Ohkubo T
动态和家庭血压（BP）可以在一段较长的时间内测量，从而产生有关血压变异性的信息。我们对日本普通人群（Ohasama）进行了20年的基于动态血压和家庭血压的发病率和死亡率监测，并证明了这些值的变异性具有独特的预后意义。夜间血压下降紊乱与脑梗死和心脏病有关，而早晨血压大幅上升和夜间血压大幅下降（类似于血压在白天大幅升高）都与脑出血有关。一天中不同时间的高血压与不同亚型的脑血管和心血管疾病风险相关。早晨和晚上的家庭血压为中风风险提供了同样有用的信息，而早晨高血压，这是专门在早晨观察到的，可能是一个很好的预测中风的指标，特别是在使用抗高血压药物的个体中。动态监测每30分钟测量一次的标准偏差估计的血压和心率变异性是独立的预测因子。也就是说，较高的短期血压变异性和较低的短期心率变异性会导致较差的心血管预后。血压的这些变化也会影响高血压的诊断和治疗，通过考虑血压的相位和强直成分，可以有效地控制高血压。
Ambulatory and home blood pressure (BP) can be measured over an extended period, thus generating information about BP variability. We have monitored a Japanese general population (Ohasama) for 20 years with respect to morbidity and mortality based on ambulatory and home BP, and have demonstrated the unique prognostic significance of variability in these values. A disturbed nocturnal decline in BP is associated with cerebral infarction and heart diseases, whereas a large morning pressor surge and a large nocturnal decline in BP, which are analogous to a large diurnal increase in BP, are both associated with cerebral hemorrhage. A high BP at various times of the day is associated with different subtypes of cerebrovascular and cardiovascular disease risk. Home BP in the morning and in the evening provide equally useful information for stroke risk, whereas morning hypertension, which is that specifically observed only in the morning, might be a good predictor of stroke, particularly among individuals using anti-hypertensive medication. The BP and heart rate variabilities estimated as standard deviation measured every 30 minutes by ambulatory monitoring are independent predictors. That is, a higher short-term BP variability with a lower short-term heart rate variability leads to a worse cardiovascular prognosis. These variations in BP also bias the diagnosis and treatment of hypertension, which can be managed effectively by considering the phasic, as well as the tonic, component of BP.
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影响因子：
3.2
作者：
Hozawa, A;Ohkubo, T;Imai, Y
通讯作者：
Imai, Y
影响因子：
3.2
作者：
Ohkubo, T;Imai, Y;Hisamichi, S
通讯作者：
Hisamichi, S
影响因子：
8.3
作者：
Asayama, K;Ohkubo, T;Imai, Y
通讯作者：
Imai, Y
影响因子：
8.3
作者：
Kikuya, Masahiro;Staessen, Jan A.;Imai, Yutaka
通讯作者：
Imai, Yutaka
影响因子：
8.3
作者：
Inoue, Ryusuke;Ohkubo, Takayoshi;Imai, Yutaka
通讯作者：
Imai, Yutaka