Vitamin D and type 2 diabetes: a systematic review.
Vitamin D and type 2 diabetes: a systematic review.
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DOI：
10.1038/ejcn.2011.118
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发表时间：
2011-09
影响因子：
4.7
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中科院分区：
文献类型：
--
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2型糖尿病的治疗方法有哪些？本综述的目的是研究维生素D状况与2型糖尿病发病之间的关系，以及补充维生素D对血糖结果的影响。我们使用MEDLINE对截至2011年2月的英语研究进行了系统回顾。纳入了报告维生素D状况与2型糖尿病发病之间相关性的纵向队列研究，以及维生素D补充剂的随机对照试验（RCT）。提取研究特征和结果，并评估研究质量。共纳入8项观察性队列研究和11项RCT。在观察性研究的荟萃分析中，与维生素D摄入量< 200 IU/天相比，维生素D摄入量> 500 IU/天可使2型糖尿病的风险降低13%。维生素D水平最高的个体（> 25 ng/ml）与维生素D水平最低的个体（< 14 ng/ml）相比，患2型糖尿病的风险降低了43%（95%置信区间为24.57%）。在对基线时葡萄糖耐量正常的受试者进行的8项试验和对确诊2型糖尿病患者进行的3项小型试验（n = 32-62）的事后分析中，维生素D补充对血糖结果没有影响。在两项针对基线葡萄糖耐受不良患者的试验中，补充维生素D可改善胰岛素抵抗。维生素D可能在2型糖尿病中发挥作用;然而，为了更好地定义维生素D在2型糖尿病发展和进展中的作用，需要高质量的观察性研究和RCT来测量血液25-羟基维生素D浓度和临床相关的血糖结果。
Vitamin D may modify the risk of type 2 diabetes mellitus. The aim of this review was to examine the association between vitamin D status and incident type 2 diabetes, and the effect of vitamin D supplementation on glycemic outcomes. We performed a systematic review of English-language studies using MEDLINE through February 2011. Longitudinal cohort studies reporting associations between vitamin D status and incident type 2 diabetes, and randomized controlled trials (RCTs) of vitamin D supplementation, were included. Study characteristics and results were extracted, and study quality was assessed. A total of 8 observational cohort studies and 11 RCTs were included. In meta-analyses of observational studies, vitamin D intake > 500 international units (IU)/day decreased the risk of type 2 diabetes by 13% compared with vitamin D intake < 200 IU/day. Individuals with the highest vitamin D status (> 25 ng/ml) had a 43% lower risk of developing type 2 diabetes (95% confidence interval 24, 57%) compared with those in the lowest group (< 14 ng/ml). In post hoc analyses from eight trials among participants with normal glucose tolerance at baseline and in three small underpowered (n = 32–62) trials of patients with established type 2 diabetes, there was no effect of vitamin D supplementation on glycemic outcomes. In two trials among patients with baseline glucose intolerance, vitamin D supplementation improved insulin resistance. Vitamin D may play a role in type 2 diabetes; however, to better define the role of vitamin D in the development and progression of type 2 diabetes, high-quality observational studies and RCTs that measure blood 25-hydroxyvitamin D concentration and clinically relevant glycemic outcomes are needed.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
7.7
作者：
Forouhi NG;Luan J;Cooper A;Boucher BJ;Wareham NJ
通讯作者：
Wareham NJ
影响因子：
11.1
作者：
Jorde, R.;Sneve, M.;Figenschau, Y.
通讯作者：
Figenschau, Y.
影响因子：
5.4
作者：
Knekt, Paul;Laaksonen, Maarit;Reunanen, Antti
通讯作者：
Reunanen, Antti
影响因子：
8.2
作者：
CAMPBELL, IT;JARRETT, RJ;KEEN, H
通讯作者：
KEEN, H