Effect of castration on the turnover of rat liver alcohol dehydrogenase.

Effect of castration on the turnover of rat liver alcohol dehydrogenase.
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去势对大鼠肝脏乙醇脱氢酶周转的影响。

DOI:
10.1016/0006-2952(85)90045-0
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发表时间:
1985
影响因子:
5.8
通讯作者:
Potter,JJ
Potter,JJ
中科院分区:
医学2区
文献类型:
--
作者:
Mezey,E;Potter,JJ

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去势可提高雄性大鼠肝脏乙醇脱氢酶活性和酶蛋白。注射NaH14CO3后,乙醇脱氢酶的转化率由免疫沉淀酶的放射性下降确定,去势后酒精脱氢酶的转化率降低。去势组的酶降解分数(Kd)为0.11d−1,而对照组为0.13d−1(P<0.05)。去势对酶的合成分数(Ks)无影响,但绝对合成速率略有增加。这项研究表明,降解速度的降低是去势后肝脏酒精脱氢酶升高的主要原因。
Castration increased liver alcohol dehydrogenase activity and enzyme protein in male rats. The turnover of alcohol dehydrogenase determined from the decline in radioactivity present in immunoprecipitated enzyme after injection of NaH14CO3was decreased after castration. The fractional rate of degradation (Kd) for the enzyme was 0.11 · day−1in the castrated as compared with 0.13 · day−1in the control animals (P < 0.05). The fractional rate of synthesis (Ks) of the enzyme was not affected by castration, while the absolute rate of synthesis was increased slightly. This study shows that a decrease in the rate of degradation is the principal cause for the increase in liver alcohol dehydrogenase following castration.
DOI: --
发表时间: 1979
影响因子: 5.8
作者:
E. Mezey;J. Potter;R. Květňanský
通讯作者: R. Květňanský
甲状腺切除联合三碘甲状腺原氨酸对大鼠肝脏乙醇脱氢酶的影响
DOI: 10.1016/0016-5085(81)90020-2
发表时间: 1981
期刊: Gastroenterology
影响因子: 29.4
作者:
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通讯作者: J. Potter
大鼠肝脏乙醇脱氢酶活性:生长激素和垂体切除术的影响。
DOI: --
发表时间: 1979
期刊: Endocrinology
影响因子: 4.8
作者:
E. Mezey;J. Potter
通讯作者: J. Potter
腺垂体对应激的反应及其下丘脑控制。
DOI: 10.1007/978-1-4684-3228-2_16
发表时间: 1972
影响因子: --
作者:
S. Mccann;L. Krulich;P. Illner;M. Quijada;K. Ajika;C. Fawcett
通讯作者: C. Fawcett
DOI: 10.1016/0006-2952(65)90225-x
发表时间: 1965
影响因子: 5.8
作者:
Gerald Weissmann
通讯作者: Gerald Weissmann