Photosensitizer drug delivery via an optical fiber.
Photosensitizer drug delivery via an optical fiber.
复制标题
DOI：
10.1021/ja200840p
复制
发表时间：
2011-05-25
影响因子：
15
通讯作者：
Greer, Alexander
中科院分区：
文献类型：
--
作者：
Zamadar, Matibur;Ghosh, Goutam;Mahendran, Adaickapillai;Minnis, Mihaela;Kruft, Bonnie I.;Ghogare, Ashwini;Aebisher, David;Greer, Alexander
已开发出一种带有可操纵微型探针尖端的光纤，可喷射氧气并光分离脱镁叶绿酸（敏化剂）分子。在探针尖端表面产生单线态氧，其与烯烃间隔基团反应，在二氧杂环丁烷中间体断裂时释放敏化剂。当探针尖端装载 60 nmol 敏化剂时，发生最佳敏化剂光释放，其中脱镁叶绿酸分子的拥挤和自猝灭保持在最低限度。光纤尖端将脱镁叶绿酸分子和单线态氧输送到离散位置。将60 nmol敏化剂输送到凡士林中；然而，甲苯-d8 (3.6 nmol) 中的敏化剂释放效率较低，即使在共价烯烃间隔键断裂后，大多数敏化剂仍吸附在探针尖端上。这些结果为光纤引导敏化剂输送的新领域打开了大门，用于需要细胞毒性控制的缺氧结构的潜在光动力疗法。
An optical fiber has been developed with a maneuverable mini-probe tip that sparges O2 gas and photo-detaches pheophorbide (sensitizer) molecules. Singlet oxygen is produced at the probe tip surface which reacts with an alkene spacer group releasing sensitizer upon fragmentation of a dioxetane intermediate. Optimal sensitizer photorelease occurred when the probe tip was loaded with 60 nmol sensitizer, where crowding of the pheophorbide molecules and self-quenching were kept to a minimum. The fiber optic tip delivered pheophorbide molecules and singlet oxygen to discrete locations. 60 nmol sensitizer was delivered into petrolatum; however, sensitizer release was less efficient in toluene-d8 (3.6 nmol) where most had remained adsorbed on the probe tip, even after the covalent alkene spacer bond had been broken. The results open the door to a new area of fiber optic-guided sensitizer delivery for the potential photodynamic therapy of hypoxic structures requiring cytotoxic control.
登录
查看更多内容
影响因子：
11.5
作者：
Hahn, Stephen M.;Putt, Mary E.;Busch, Theresa M.
通讯作者：
Busch, Theresa M.
影响因子：
3.3
作者：
Berg, K;Moan, J
通讯作者：
Moan, J
影响因子：
15
作者：
Hu, J;Zhang, J;Fox, MA
通讯作者：
Fox, MA
影响因子：
4.7
作者：
Gabriel, Doris;Campo, Marino A.;Lange, Norbert
通讯作者：
Lange, Norbert
影响因子：
3.3
作者：
Campo, Marino A.;Gabriel, Doris;Lange, Norbert
通讯作者：
Lange, Norbert