Utilization of different anti-viral mechanisms by mammalian embryonic stem cells and differentiated cells.
Utilization of different anti-viral mechanisms by mammalian embryonic stem cells and differentiated cells.
复制标题
哺乳动物胚胎干细胞和分化细胞利用不同的抗病毒机制。
DOI：
10.1038/icb.2016.70
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发表时间：
2017-01
影响因子：
4
通讯作者：
Guo YL
中科院分区：
文献类型：
--
作者：
Guo YL
胚胎干细胞（Embryonic stem cells，ESCs）因其在再生医学中的潜在应用而受到广泛关注。在过去的二十年里，深入的研究不仅导致了从ESCs中产生各种类型的细胞，这些细胞可用于治疗人类疾病，而且还导致了新概念的形成和突破，这些新概念和突破极大地影响了我们对基础细胞生物学和发育生物学的理解。最近的研究表明，胚胎干细胞和其他类型的多能细胞不具有功能性干扰素（IFN）为基础的抗病毒机制，挑战的想法，IFN系统开发的抗病毒先天免疫的所有类型的细胞在脊椎动物的核心组成部分。这一发现也为一个长期以来一直不确定的问题提供了重要的见解：RNA干扰（RNAi）抗病毒机制是否在哺乳动物细胞中起作用。一个新兴的范例是，哺乳动物可能在生物体发育的不同阶段适应了不同的抗病毒机制;基于IFN的系统主要由分化的体细胞利用，而RNAi抗病毒机制可能用于ESC。本文讨论了哺乳动物在发育过程中具有不同抗病毒机制的分子基础和生物学意义。
Embryonic stem cells (ESCs) have received tremendous attention because of their potential applications in regenerative medicine. Over the past two decades, intensive research has not only led to the generation of various types of cells from ESCs that can be potentially used for the treatment of human diseases, but also led to the formation of new concepts and breakthroughs that have significantly impacted our understanding of basic cell biology and developmental biology. Recent studies have revealed that ESCs and other types of pluripotent cells do not have a functional interferon (IFN)-based antiviral mechanism, challenging the idea that the IFN system is developed as the central component of antiviral innate immunity in all types of cells in vertebrates. This finding also provided important insight into a question that has been uncertain for a long time: whether or not the RNA interference (RNAi) antiviral mechanism operates in mammalian cells. An emerging paradigm is that mammals may have adapted distinct antiviral mechanisms at different stages of organismal development; the IFN-based system is mainly utilized by differentiated somatic cells while the RNAi antiviral mechanism may be used in ESCs. This paper discusses the molecular basis and biological implications for mammals to have different antiviral mechanisms during development.
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影响因子：
23.9
作者：
Dalton S
通讯作者：
Dalton S
DOI：
10.1002/stem.2079
发表时间：
2015-11
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Guo YL;Carmichael GG;Wang R;Hong X;Acharya D;Huang F;Bai F
通讯作者：
Bai F
影响因子：
5.4
作者：
Chen, Guan-Yu;Hwang, Shiaw-Min;Hu, Yu-Chen
通讯作者：
Hu, Yu-Chen
影响因子：
3.7
作者：
Foeldes, Gabor;Liu, Alexander;Mitchell, Jane A.
通讯作者：
Mitchell, Jane A.
影响因子：
4.8
作者：
Hong, Xiao-Xiao;Carmichael, Gordon G.
通讯作者：
Carmichael, Gordon G.