A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants
A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants
复制标题
在患有多种变异的母亲所生的婴儿中发现了一种独特的主要丙型肝炎病毒变异
作者：
A. Weiner;M. Thaler;K. Crawford;K. Ching;J. Kansopon;D. Chien;J. Hall;F. Hu;M. Houghton
为了证实丙型肝炎病毒(丙型肝炎病毒)从感染丙型肝炎病毒的非人类免疫缺陷病毒1型感染的母亲向婴儿的垂直传播，并评估病毒种类在母婴中的分布，对3名母亲和1对母婴进行了编码包膜糖蛋白E2(E2HV)基因的高变区测序。数据表明：(I)在所有四位母亲中都发现了丙型肝炎病毒E2HV变种的准物种分布，(Ii)在一名母亲的婴儿中发现了一个主要的丙型肝炎病毒E2HV变种，该婴儿具有九种主要的E2HV变种，以及(Iii)婴儿的E2HV变种与出生时在母亲体内发现的九种变种高度相关，但不完全相同。这些发现表明，丙型肝炎病毒是由母亲传播给婴儿的，这增加了这种传播发生在子宫内的可能性。
To demonstrate vertical transmission of hepatitis C virus (HCV) from an HCV-infected, non-human immunodeficiency virus type 1-infected mother to her infant and to assess the distribution of viral species in the mother and infant, the hypervariable region of the gene encoding the putative envelope glycoprotein E2 (E2HV) was sequenced in three mothers and one mother-infant pair. The data indicate that (i) quasi-species distributions of HCV E2HV variants were found in all four mothers, (ii) a single predominant HCV E2HV variant was found in the infant of a mother shown to have nine predominant E2HV variants, and (iii) the infant's E2HV variant was highly related to, but not identical with, the nine variants identified in the mother at the time of birth. These findings indicate that HCV is transmitted from mother to infant and raise the possibility that the transmission occurs in utero.
影响因子：
56.9
作者：
WOLINSKY, SM;WIKE, CM;MUNOZ, JL
通讯作者：
MUNOZ, JL