Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: a beta-CIT imaging study.
Occupational exposure to PCBs reduces striatal dopamine transporter densities only in women: a beta-CIT imaging study.
复制标题
DOI：
10.1016/j.nbd.2010.01.009
复制
发表时间：
2010-05
影响因子：
6.1
通讯作者：
McCaffrey RJ
中科院分区：
文献类型：
--
作者：
Seegal RF;Marek KL;Seibyl JP;Jennings DL;Molho ES;Higgins DS;Factor SA;Fitzgerald EF;Hills EA;Korrick SA;Wolff MS;Haase RF;Todd AC;Parsons P;McCaffrey RJ
我们假设，职业暴露于多氯联苯是与减少中枢多巴胺（DA）类似的变化，以前看到在PCB暴露的成年非人灵长类动物。为了验证这一假设，我们使用[123 I]β-CIT SPECT成像来估计前电容器工人的基底节DA转运蛋白密度。女性，但不是男性，显示了血脂调整后的总血清PCB浓度和DA转运蛋白密度之间的负相关关系，在血清PCB浓度的差异。这些性别差异可能反映了年龄相关的性腺激素水平的降低，因为这些激素已被实验证明，改变DA神经毒物的反应。这些研究结果可能有助于更好地理解的作用，性别和年龄发挥在修改中央DA功能暴露后，不仅多氯联苯，但也对其他DA神经毒物，以及进一步阐明性腺激素的作用，在影响神经退行性疾病的启动和/或进展。
We hypothesize that occupational exposure to PCBs is associated with a reduction in central dopamine (DA) similar to changes previously seen in PCB exposed adult non-human primates. To test that hypothesis we used [123I]β-CIT SPECT imaging to estimate basal ganglia DA transporter density in former capacitor workers. Women, but not men, showed an inverse relationship between lipid-adjusted total serum PCB concentrations and DA transporter densities in the absence of differences in serum PCB concentrations. These sex differences may reflect age-related reductions in the levels of gonadal hormones since these hormones have been shown experimentally to alter response to DA neurotoxicants. These findings may aid in better understanding the roles that sex and age play in modifying central DA function following exposure, not only to PCBs, but also to other DA neurotoxicants as well as further elucidating the role of gonadal hormones in influencing the initiation and/or progression of neurodegenerative disorders.
登录
查看更多内容
影响因子：
4
作者：
PHILLIPS, DL;PIRKLE, JL;NEEDHAM, LL
通讯作者：
NEEDHAM, LL
DOI：
10.1016/s0169-328x(97)00082-x
发表时间：
1997-06-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Bosse, R;Rivest, R;DiPaolo, T
通讯作者：
DiPaolo, T
影响因子：
3.8
作者：
Bemis, JC;Seegal, RF
通讯作者：
Seegal, RF
DOI：
10.1111/j.1749-6632.1979.tb13180.x
发表时间：
1979-05-31
影响因子：
5.2
作者：
Horn, E G;Hetling, L J;Tofflemire, T J
通讯作者：
Tofflemire, T J
影响因子：
10.4
作者：
LAWTON, RW;ROSS, MR;BROWN, JF
通讯作者：
BROWN, JF