Synaptic efficacy and reliability of excitatory connections between the principal neurones of the input (layer 4) and output layer (layer 5) of the neocortex
Synaptic efficacy and reliability of excitatory connections between the principal neurones of the input (layer 4) and output layer (layer 5) of the neocortex
复制标题
新皮质输入层（第 4 层）和输出层（第 5 层）主要神经元之间兴奋性连接的突触功效和可靠性
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
B. Sakmann
中科院分区：
文献类型：
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作者：
D. Feldmeyer;B. Sakmann
理解皮质柱如何运作的先决条件是描述仅由少数已识别的神经元组成的小而明确的神经元回路。在这里，我们总结了两种突触连接的形态学和生理学特性，即第4层的成对棘神经元和第5层的成对锥体细胞之间的突触连接。第4层棘神经元是皮层输入神经元，放大和传递来自外周的传入兴奋，第5层锥体细胞整合皮层柱内和跨皮层柱的神经元活动，随后将其分布到皮层和皮层下脑区。
A prerequisite for the understanding of how a cortical column functions is a description of small and defined neuronal circuits consisting of only a few identified neurones. Here we summarise, with particular reference to the barrel cortex, the morphological and physiological properties of two synaptic connections, namely those between pairs of spiny neurones in layer 4 and pairs of pyramidal cells in layer 5. While layer 4 spiny neurones are the cortical input neurones that amplify and relay incoming excitation from the periphery, layer 5 pyramidal cells integrate neuronal activity both within and across cortical columns and subsequently distribute it to both cortical and subcortical brain regions.
影响因子：
2.5
作者：
ARMSTRONGJAMES, M;FOX, K;DASGUPTA, A
通讯作者：
DASGUPTA, A