Impact of Panel Gene Testing for Hereditary Breast and Ovarian Cancer on Patients.
Impact of Panel Gene Testing for Hereditary Breast and Ovarian Cancer on Patients.
复制标题
面板基因测试对遗传性乳腺癌和卵巢癌对患者的影响。
DOI：
10.1007/s10897-017-0090-y
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发表时间：
2017-10
影响因子：
1.9
通讯作者：
Chung WK
中科院分区：
文献类型：
--
作者：
Lumish HS;Steinfeld H;Koval C;Russo D;Levinson E;Wynn J;Duong J;Chung WK
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Recent advances in next generation sequencing have enabled panel gene testing, or simultaneous testing for mutations in multiple genes for a clinical condition. With more extensive and widespread genetic testing, there will be increased detection of genes with moderate penetrance without established clinical guidelines and of variants of uncertain significance (VUS), or genetic variants unknown to either be disease-causing or benign. This study surveyed 232 patients who underwent genetic counseling for hereditary breast and ovarian cancer to examine the impact of panel gene testing on psychological outcomes, patient understanding, and utilization of genetic information. The survey used standardized instruments including the Impact of Event Scale (IES), Multidimensional Impact of Cancer Risk Assessment (MICRA), Satisfaction with Decision Instrument (SWD), Ambiguity Tolerance Scale (AT-20), genetics knowledge, and utilization of genetic test results. Study results suggested that unaffected individuals with a family history of breast or ovarian cancer who received positive results were most significantly impacted by intrusive thoughts, avoidance, and distress. However, scores were also modestly elevated among unaffected patients with a family history of breast and ovarian cancer who received VUS, highlighting the impact of ambiguous results that are frequent among patients undergoing genetic testing with large panels of genes. Potential risk factors for increased genetic testing-specific distress in this study included younger age, black or African American race, Hispanic origin, lower education level, and lower genetic knowledge and highlight the need for developing strategies to provide effective counseling and education to these communities, particularly when genetic testing utilizes gene panels that more commonly return VUS. More detailed pre-test education and counseling may help patients appreciate the probability of various types of test results and how results would be used clinically, and allow them to make more informed decisions about the type of genetic testing to select.
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影响因子：
2.1
作者：
Lynch, Henry T.;Silva, Edibaldo;Lynch, Jane F.
通讯作者：
Lynch, Jane F.
DOI：
10.1158/1055-9965.epi-11-0991
发表时间：
2012-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Graves KD;Vegella P;Poggi EA;Peshkin BN;Tong A;Isaacs C;Finch C;Kelly S;Taylor KL;Luta G;Schwartz MD
通讯作者：
Schwartz MD
DOI：
10.1038/gim.2014.40
发表时间：
2014-11
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
1.9
作者：
MacDonald, Deborah J.;Sarna, Linda;Ferrell, Betty
通讯作者：
Ferrell, Betty
影响因子：
3.6
作者：
HolmesRovner, M;Kroll, J;Talarczyk, G
通讯作者：
Talarczyk, G