Norfloxacin: a new targeted fluoroquinolone antimicrobial agent.
Norfloxacin: a new targeted fluoroquinolone antimicrobial agent.
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诺氟沙星：一种新型靶向氟喹诺酮类抗菌药物。
DOI：
10.7326/0003-4819-108-2-238
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发表时间：
1988
影响因子：
39.2
通讯作者：
D. Hooper
中科院分区：
文献类型：
--
作者：
J. Wolfson;D. Hooper
诺氟沙星是一种口服氟喹诺酮类抗菌药物，最近被用于治疗单纯性和复杂性尿路感染。该药物拮抗DNA回旋酶，这是细菌DNA复制所必需的酶。诺氟沙星比早期开发的类似物萘啶酸更有效，谱更广，并且在体外对几乎所有引起尿路和胃肠道感染的细菌病原体、引起贫血患者败血症的需氧革兰氏阴性杆菌和淋病奈瑟菌都有活性。该药物每天口服两次，在尿液、粪便、肾组织和胆汁中达到高浓度。诺氟沙星在治疗尿路感染方面至少与目前使用的药物一样有效，在有限的研究中，诺氟沙星对细菌性胃肠炎、淋病、细菌性前列腺炎和预防贫血患者的革兰氏阴性杆菌感染也同样有效。药物不良反应轻微，包括胃肠道和中枢神经系统紊乱。诺氟沙星显示出作为泌尿生殖道和胃肠道感染的抗菌剂的前景。
Norfloxacin is an oral fluoroquinolone antimicrobial agent recently released for the treatment of uncomplicated and complicated urinary tract infections. The drug antagonizes DNA gyrase, an enzyme essential for bacterial DNA replication. Norfloxacin is more potent and broader in spectrum than the earlier developed analogue, nalidixic acid, and is active in vitro against virtually all bacterial pathogens causing urinary tract and gastrointestinal infections, aerobic gram-negative bacilli causing sepsis in neutropenic patients, and Neisseria gonorrhoeae. The drug is administered orally twice daily and achieves high concentrations in urine, stool, renal tissue, and bile. Norfloxacin was at least as effective as currently used agents in treating urinary tract infections, and, in limited studies, bacterial gastroenteritis, gonorrhea, bacterial prostatitis, and prevention of gram-negative bacillary infection in neutropenic patients. Adverse drug effects were mild and included disturbances of the gastrointestinal tract and the central nervous system. Norfloxacin shows promise as an antibacterial agent for genitourinary and gastrointestinal infections.
急性白血病口服甲氧苄啶-磺胺甲恶唑预防失败：从引起菌血症的肠杆菌科菌株中分离耐药质粒。
DOI：
10.1056/nejm198201073060105
发表时间：
1982
期刊：
The New England journal of medicine
影响因子：
--
作者：
Wilson,JM;Guiney,DG
通讯作者：
Guiney,DG
氧氟沙星与万古霉素/多粘菌素用于预防粒细胞减少症患者的感染。
DOI：
10.1016/0002-9343(90)90125-w
发表时间：
1990
期刊：
The American journal of medicine
影响因子：
--
作者：
Winston,DJ;Ho,WG;Bruckner,DA;Gale,RP;Champlin,RE
通讯作者：
Champlin,RE
诺氟沙星用于预防粒细胞减少症患者的细菌感染。
DOI：
10.1016/0002-9343(87)90617-6
发表时间：
1987
期刊：
The American journal of medicine
影响因子：
--
作者：
Winston,DJ;Ho,WG;Champlin,RE;Karp,J;Bartlett,J;Finley,RS;Joshi,JH;Talbot,G;Levitt,L;Deresinski,S
通讯作者：
Deresinski,S