Re: Regenerative Potential of Prostate Luminal Cells Revealed by Single-cell Analysis.
Re: Regenerative Potential of Prostate Luminal Cells Revealed by Single-cell Analysis.
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DOI：
10.1016/j.eururo.2020.08.017
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发表时间：
2021-01
期刊：
影响因子：
23.4
通讯作者：
Kyprianou N
中科院分区：
文献类型：
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作者：
Kyprianou N
前列腺癌是男性的附属器官，有助于射精，它的生长依赖于雄激素。去势诱导的雄激素剥夺会导致依赖雄激素的上皮细胞的凋亡，导致前列腺迅速退化，而作为对雄激素替代的反应，腺体会再生[1]。正常前列腺的上皮谱系包括基细胞和管腔分泌细胞，它们构成前列腺腺上皮的大部分，周围有间质，包括成纤维细胞、内皮细胞、神经和干/祖细胞。Karthaus等人的研究表明，退缩后的前列腺再生不仅通过干细胞，还通过一组持久的腔上皮细胞。来自成年小鼠和人类衍生器官的前列腺腔细胞表达干细胞样基因和分化基因，这些基因在雄激素耗竭的情况下持续存在。单细胞图谱揭示了前列腺细胞谱系中的一个共同的基因簇，包括NKx3-1、PSCA(干状)、AR调节基因和Neureogelin-2(腔再生的间质细胞驱动因素)，它们促进腺体对雄激素的再生长。
Growth of the prostate gland, a male sex accessory organ that contributes to ejaculate fluid, is dependent on androgens. Castration-induced androgen deprivation leads to rapid involution of the prostate due to apoptosis of androgen-dependent epithelial cells, while in response to androgen replacement there is regeneration of the gland [1]. The epithelial lineage hierarchy for a normal prostate gland involves basal and luminal secretory cells, which constitute most of the prostate glandular epithelium, surrounded by stroma, which contains fibroblasts, endothelial cells, nerves, and stem/progenitor cells. The study by Karthaus et al revealed that prostate regeneration after involution occurs not only via stem cells but also via a subset of persisting luminal epithelial cells. Prostate luminal cells from adult mouse and human-derived organoids express stem-like and differentiation genes that are sustained under androgen depletion. Single-cell profiling unveiled a shared gene cluster in the prostate cell lineage, comprising NKx3–1, PSCA (stem-like), AR-regulated genes, and neureogelin-2 (mesenchymal cell driver of luminal regeneration), that promote regrowth of the gland in response to androgens.
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影响因子：
2.8
作者：
Isaacs, John T.
通讯作者：
Isaacs, John T.
影响因子：
8.8
作者：
Barros-Silva, Joao D.;Linn, Douglas E.;Baena, Esther
通讯作者：
Baena, Esther
DOI：
10.1007/978-3-030-32656-2_4
发表时间：
2019-01-01
期刊：
PROSTATE CANCER: CELLULAR AND GENETIC MECHANISMS OF DISEASE DEVELOPMENT AND PROGRESSION, 2ND EDITION
影响因子：
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作者：
Xin, Li
通讯作者：
Xin, Li
影响因子：
4.8
作者：
KYPRIANOU, N;ISAACS, JT
通讯作者：
ISAACS, JT
影响因子：
64.8
作者：
通讯作者：
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