Cognitive performance in antidepressant-free recurrent major depressive disorder.
Cognitive performance in antidepressant-free recurrent major depressive disorder.
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DOI：
10.1002/da.22747
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发表时间：
2018-08
影响因子：
7.4
通讯作者：
Taylor WD
中科院分区：
文献类型：
--
作者：
Albert KM;Potter GG;McQuoid DR;Taylor WD
认知主诉在抑郁症中很常见，认知可能是一个重要的治疗目标，因为认知问题通常在缓解期间仍然存在，并可能导致复发风险。以前对抑郁症认知表现的研究主要是研究晚年抑郁症，重点是老年人，或者评估特定认知任务而不是认知领域的表现。本研究探讨了在多个认知领域的认知表现在抗抑郁药免费抑郁症的早发复发性抑郁症的成年人相比，从未抑郁症的控制。计算情景记忆、执行功能、处理速度和工作记忆的领域分数，并检查抑郁症诊断、抑郁症严重程度和抑郁症持续时间对每个领域分数的影响，包括与年龄、性别和教育的相互作用。目前抑郁的成年人（n = 91）表现出较差的性能在处理速度域相比，从未抑郁的成年人（n = 105）。此外，抑郁持续时间和年龄对处理速度和执行功能领域的表现有交互作用，年龄越大，抑郁持续时间越长，表现越差。抑郁症的严重程度对认知领域的表现没有影响。这些发现支持了处理速度缺陷出现在早发性抑郁症的年轻人中，这可能与当前情绪无关。此外，累积抑郁发作的影响可能与衰老相互作用，使得认知表现缺陷随着寿命的复发而恶化。
Cognitive complaints are common in depression, and cognition may be an important treatment target as cognitive problems often remain during remission and may contribute to recurrence risk. Previous studies of cognitive performance in depression have mainly examined late-life depression, with a focus on older adults, or assessed performance in specific cognitive tasks rather than cognitive domains. This study examined cognitive performance across multiple cognitive domains in antidepressant-free depressed adults with early onset recurrent depression compared to never-depressed controls. Domain scores were calculated for episodic memory, executive function, processing speed, and working memory, and the effect of depression diagnosis, depression severity, and depression duration on each domain score was examined, including interactions with age, sex, and education. Currently depressed adults (n = 91) exhibited poorer performance in the processing speed domain compared with never-depressed adults (n = 105). Additionally, there was an interactive effect of depression duration and age on processing speed and executive function domain performance, such that performance was worse with older age and longer duration of depression. There were no effects of depression severity on performance across the cognitive domains. These findings support that processing speed deficits appear in young adults with early onset depression that may not be related to current mood. Additionally, the effects of cumulative depressive episodes may interact with aging such that cognitive performance deficits worsen with recurrence over the lifespan.
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影响因子：
6.9
作者：
Fritzsche, A.;Dahme, B.;Gotlib, I. H.;Joormann, J.;Magnussen, H.;Watz, H.;Nutzinger, D. O.;von Leupoldt, A.
通讯作者：
von Leupoldt, A.
影响因子：
7.4
作者：
Joormann, Jutta;Quinn, Meghan E.
通讯作者：
Quinn, Meghan E.
影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
Harvey, Philip D.
影响因子：
3.7
作者：
Park, DC;Lautenschlager, G;Smith, PK
通讯作者：
Smith, PK
DOI：
10.1111/j.1532-5415.1968.tb02103.x
发表时间：
1968-01-01
影响因子：
6.3
作者：
LINN, BS;LINN, MW;GUREL, L
通讯作者：
GUREL, L