Upregulation of epidermal growth factor receptor 4 in oral leukoplakia.
Upregulation of epidermal growth factor receptor 4 in oral leukoplakia.
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DOI：
10.1038/ijos.2013.10
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发表时间：
2013-03
影响因子：
14.9
通讯作者：
Suzuki, Ryuji
中科院分区：
文献类型：
--
作者：
Kobayashi, Hiroshi;Kumagai, Kenichi;Gotoh, Akito;Eguchi, Takanori;Yamada, Hiroyuki;Hamada, Yoshiki;Suzuki, Satsuki;Suzuki, Ryuji
关键词：
在本研究中，我们调查的表皮生长因子受体家族，其中包括EGFR/ErbB 1，HER 2/ErbB 2，HER 3/ErbB 3和HER 4/ErbB 4在口腔白斑（LP）的表达谱。应用实时荧光定量PCR和免疫组化方法检测14例扁平苔藓组织中表皮生长因子受体（EGFR）家族基因及其配体的表达，并与10例口腔扁平苔藓（OLP）和14例健康人正常口腔粘膜（NOM）进行比较。ErbB 1、ErbB 2、ErbB 3和ErbB 4在LP病变中同步表达。在所有受体中，只有ErbB 4 mRNA和蛋白在LP中的表达高于NOM组织。免疫组织化学显示，LP病变中的上皮角质形成细胞强烈表达这些蛋白。关于配体，与NOM组织相比，OLP中Neuregulin 2和Neuregulin 4的mRNA表达更高。因此，ErbB 4在角质形成细胞上的表达增强和EGFR家族基因的同步调节可能参与LP的发病和癌变。
In the present study, we investigate the expression profile of the epidermal growth factor receptor family, which comprises EGFR/ErbB1, HER2/ErbB2, HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia (LP). The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus (OLP) and normal oral mucosa (NOM) from 14 healthy donors by real-time polymerase chain reaction (PCR) and immunohistochemistry. Synchronous mRNA coexpression of ErbB1, ErbB2, ErbB3 and ErbB4 was detected in LP lesions. Out of the receptors, only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM tissues. These were strongly expressed by epithelial keratinocytes in LP lesions, as shown by immunohistochemistry. Regarding the ligands, the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM tissues. Therefore, enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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