Nonalcoholic fatty liver disease as a predictor of atrial fibrillation: a systematic review and meta-analysis.
Nonalcoholic fatty liver disease as a predictor of atrial fibrillation: a systematic review and meta-analysis.
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DOI：
10.5114/aic.2017.70198
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Sun C
中科院分区：
文献类型：
--
作者：
Zhou Y;Lai C;Peng C;Chen M;Li B;Wang X;Sun J;Sun C
许多流行病学研究调查了非酒精性脂肪肝（NAFLD）和长期房颤（AF）风险之间的联系，但结果令人惊讶地相互矛盾。因此，我们系统地回顾了所有已发表的评估NAFLD患者AF风险的研究，并进行了荟萃分析。我们于2017年2月使用PubMed、EMBASE和科克伦图书馆数据库进行了文献检索，无任何限制。在这项荟萃分析中确定了两项队列研究和两项横断面研究，共涉及5150例受试者（NAFLD：1655例;对照：3495例）。提取选定研究的数据，并使用随机效应模型进行荟萃分析。与对照组相比，非酒精性脂肪肝患者的AF风险显著更高（相对风险（RR）：2.61; 95%置信区间（CI）：1.34-5.06，p = 0.00; I2 = 52.5%，p = 0.097）。在根据2型糖尿病分层的进一步分析中，风险增加主要存在于2型糖尿病患者中（RR = 5.10; 95%CI：2.43-10.7，p < 0.001; I2 = 0，p = 0.958）。然而，无2型糖尿病的受试者发生AF的风险略有增加，但相对风险未达到统计学显著性（RR = 1.68; 95% CI：0.99-2.82，p = 0.05; I2 = 0，p = 0.461）。我们的荟萃分析表明，超声诊断的NAFLD患者在调整了许多重要的AF临床危险因素后，AF的风险明显较高。这些结果需要在大型前瞻性研究中得到证实。
Numerous epidemiologic studies have investigated the link between nonalcoholic fatty liver disease (NAFLD) and long-term atrial fibrillation (AF) risk, but the results are surprisingly conflicting. Therefore, we systematically reviewed all published studies assessing the risk of AF in patients with NAFLD and conducted a meta-analysis. We performed a literature search using PubMed, EMBASE and Cochrane Library databases in February 2017 with no restrictions. Two cohort studies and two cross-sectional studies were identified, involving a total of 5150 subjects (NAFLD: 1655; controls: 3495) in this meta-analysis. Data from selected studies were extracted and a meta-analysis was performed using a random effects model. Nonalcoholic fatty liver disease patients had a significantly higher risk of AF compared to controls (relative risk (RR): 2.61; 95% confidence interval (CI): 1.34–5.06, p = 0.00; I2 = 52.5%, p = 0.097). In a further analysis stratified by presence of type 2 diabetes, the increased risk was present predominantly in patients with type 2 diabetes (RR = 5.10; 95% CI: 2.43–10.7, p < 0.001; I2 = 0, p = 0.958). However, subjects without type 2 diabetes were at slightly increased risk of AF but the relative risk did not reach statistical significance (RR = 1.68; 95% CI: 0.99–2.82, p = 0.05; I2 = 0, p = 0.461). Our meta-analysis suggested that ultrasound-diagnosed NAFLD patients have a significantly higher risk for AF after adjustment for numerous important clinical risk factors for AF. These results need to be confirmed in large prospective studies.
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影响因子：
3.7
作者：
Kato K;Takamura T;Takeshita Y;Ryu Y;Misu H;Ota T;Tokuyama K;Nagasaka S;Matsuhisa M;Matsui O;Kaneko S
通讯作者：
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影响因子：
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作者：
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DOI：
10.1161/atvbaha.114.303034
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
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影响因子：
4.3
作者：
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通讯作者：
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