Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.
Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.
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绵羊运动障碍前心尖左心室动脉瘤心室补片成形术后左心室容量和功能。
DOI：
10.1016/j.jtcvs.2005.05.039
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Ratcliffe,MarkB
中科院分区：
文献类型：
--
作者：
Zhang,Peng;Guccione,JuliusM;Nicholas,SusanI;Walker,JosephC;Crawford,PhilipC;Shamal,Amin;Saloner,DavidA;Wallace,ArthurW;Ratcliffe,MarkB
目的：室内补片成形术（Dor手术）作为一种外科治疗心衰合并大面积心尖前心肌梗死的方法已获得青睐。我们检验了Dor手术减少左心室容积、增加收缩末期弹性、降低舒张顺应性和维持左心室功能的假设。方法将6只雄性多赛特羊的左冠状动脉前降支及其第二斜支结扎在冠状动脉顶端至底端距离的40%处。心肌梗死16周后，用50%梗死颈部尺寸的涤纶贴片进行Dor手术。磁共振成像测量左心室绝对容积，在Dor手术前2周、后2周和6周用容积导管测量药理学预负荷减轻过程中左心室压力和相对左心室容积变化。收缩期末期弹性、舒张顺应性和斯塔林关系由左心室压力/容积循环计算。结果Dor术后2周左室收缩期末和舒张期末容积均明显减小，6周无再扩张。Dor手术后6周，射血分数明显升高。虽然6周时脑卒中量略有增加，但变化不显著。在2周和6周时，收缩末期弹性、舒张顺应性和Starling关系的斜率不变。结论Dor术可显著降低左心室容积。与线性修复不同，左心室容积变化似乎是稳定的。射血分数得到改善，左心室功能（脑卒中容量和斯塔林关系）得以维持。
OBJECTIVEEndoventricular patch plasty (the Dor procedure) has gained favor as a surgical treatment for heart failure associated with large anteroapical myocardial infarction. We tested the hypothesis that the Dor procedure reduces left ventricular volume, increases end-systolic elastance, decreases diastolic compliance, and maintains left ventricular function.METHODSIn 6 male Dorsett sheep, the left anterior descending coronary artery and its second diagonal branch were ligated 40% of the distance from apex to base. Sixteen weeks after myocardial infarction, a Dor procedure was performed with a Dacron patch that was 50% of the infarct neck dimension. Absolute left ventricular volume was measured with magnetic resonance imaging, and left ventricular pressure and relative left ventricular volume changes during pharmacologic preload reduction were measured with a volume conductance catheter 2 weeks before and 2 and 6 weeks after the Dor procedure. End-systolic elastance, diastolic compliance, and Starling relationships were calculated from the resultant left ventricular pressure/volume loops.RESULTSTwo weeks after the Dor procedure, the left ventricular volume at end systole and end diastole was significantly reduced, and there was no redilation at 6 weeks. Six weeks after the Dor procedure, the ejection fraction was significantly increased. Although stroke volume increased slightly at 6 weeks, the change was not significant. The slopes of end-systolic elastance, diastolic compliance, and Starling relationships were unchanged at 2 and 6 weeks.CONCLUSIONSThe Dor procedure significantly reduces left ventricular volume. Unlike linear repair, left ventricular volume changes seem stable. The ejection fraction is improved, and left ventricular function (stroke volume and the Starling relationship) is maintained.
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影响因子：
4.6
作者：
MARKOVITZ, LJ;SAVAGE, EB;EDMUNDS, LH
通讯作者：
EDMUNDS, LH
DOI：
10.1016/s0022-5223(95)70052-8
发表时间：
1995-11-01
影响因子：
6
作者：
DOR, V;SABATIER, M;MONTIGLIO, F
通讯作者：
MONTIGLIO, F
心室减容手术对扩张、收缩不良的左心室的影响：简单的有限元分析。
影响因子：
6
作者：
M. Ratcliffe;J. Hong;A. Salahieh;S. Ruch;A. Wallace
通讯作者：
A. Wallace
DOI：
10.1016/s0735-1097(02)02121-6
发表时间：
2002-09-18
影响因子：
24
作者：
Jackson, BM;Gorman, JH;Gorman, RC
通讯作者：
Gorman, RC
手术前室心内膜修复（SAVER）治疗扩张型缺血性心肌病。
影响因子：
2.5
作者：
C. Athanasuleas;A. Stanley;G. Buckberg;V. Dor;M. Donato;W. Siler
通讯作者：
W. Siler