Neuroergonomic assessment of developmental coordination disorder.
Neuroergonomic assessment of developmental coordination disorder.
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发育协调障碍的神经工效学评估。
DOI：
10.1038/s41598-022-13966-9
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发表时间：
2022-06-17
影响因子：
4.6
通讯作者：
Ayaz, Hasan
中科院分区：
文献类型：
--
作者：
Joshi, Shawn;Weedon, Benjamin D.;Esser, Patrick;Liu, Yan-Ci;Springett, Daniella N.;Meaney, Andy;Inacio, Mario;Delextrat, Anne;Kemp, Steve;Ward, Tomas;Izadi, Hooshang;Dawes, Helen;Ayaz, Hasan
直到最近，粗大运动协调的神经评估还不能可靠地处理主动任务，特别是在现实环境中，并且提供了对运动认知的狭隘理解。通过应用光学移动的神经成像的综合神经人体工程学方法，我们探讨了与发展协调障碍（DCD），运动学习缺陷影响5-6%的儿童终身并发症的年轻人的运动功能的神经相关性。使用fNIRS的神经记录，收集在主动走动的行为任务执行从37个典型的发展和48个DCD儿童进行认知和身体的任务，在单一和双重条件。这是第一项针对前额叶皮质功能障碍区域的研究，用于在现实运动任务中识别DCD的神经病理生理学，也是涉及DCD的最大神经影像学研究（所有模式）之一。我们证明了DCD是一种运动认知障碍，因为通过功能性近红外光谱分析，粗大运动/复杂任务显示右额中回和额上级回的神经血流动力学缺陷和功能障碍。此外，通过纳入行为表现，在这些地区的神经效率下降，显示在儿童与DCD，特别是在运动任务。最后，我们提供了一个框架，在生态有效的背景下评估疾病的影响，以确定何时以及对谁最需要介入方法，并为精确治疗打开大门。
Until recently, neural assessments of gross motor coordination could not reliably handle active tasks, particularly in realistic environments, and offered a narrow understanding of motor-cognition. By applying a comprehensive neuroergonomic approach using optical mobile neuroimaging, we probed the neural correlates of motor functioning in young people with Developmental Coordination Disorder (DCD), a motor-learning deficit affecting 5–6% of children with lifelong complications. Neural recordings using fNIRS were collected during active ambulatory behavioral task execution from 37 Typically Developed and 48 DCD Children who performed cognitive and physical tasks in both single and dual conditions. This is the first of its kind study targeting regions of prefrontal cortical dysfunction for identification of neuropathophysiology for DCD during realistic motor tasks and is one of the largest neuroimaging study (across all modalities) involving DCD. We demonstrated that DCD is a motor-cognitive disability, as gross motor /complex tasks revealed neuro-hemodynamic deficits and dysfunction within the right middle and superior frontal gyri of the prefrontal cortex through functional near infrared spectroscopy. Furthermore, by incorporating behavioral performance, decreased neural efficiency in these regions were revealed in children with DCD, specifically during motor tasks. Lastly, we provide a framework, evaluating disorder impact in ecologically valid contexts to identify when and for whom interventional approaches are most needed and open the door for precision therapies.
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影响因子：
11.2
作者：
Ernst, Thomas;Yakupov, Renat;Nakama, Helenna;Crocket, Grace;Cole, Michael;Watters, Michael;Ricardo-Dukelow, Mary Lynn;Chang, Linda
通讯作者：
Chang, Linda
识别发育性运动困难：评估儿童运动协调性的测试回顾。
影响因子：
--
作者：
Cancer A;Minoliti R;Crepaldi M;Antonietti A
通讯作者：
Antonietti A
影响因子：
17.1
作者：
Emerson RW;Adams C;Nishino T;Hazlett HC;Wolff JJ;Zwaigenbaum L;Constantino JN;Shen MD;Swanson MR;Elison JT;Kandala S;Estes AM;Botteron KN;Collins L;Dager SR;Evans AC;Gerig G;Gu H;McKinstry RC;Paterson S;Schultz RT;Styner M;IBIS Network;Schlaggar BL;Pruett JR Jr;Piven J
通讯作者：
Piven J
影响因子：
2
作者：
Girgenrath, Michaela;Bock, Otmar;Seitz, Ruediger J.
通讯作者：
Seitz, Ruediger J.
影响因子：
6.9
作者：
George MS;Taylor JJ;Short EB
通讯作者：
Short EB