Evaluation of using the Doppler shift effect of prompt gamma for measuring the carbon ion range in vivo for heterogeneous phantoms
Evaluation of using the Doppler shift effect of prompt gamma for measuring the carbon ion range in vivo for heterogeneous phantoms
复制标题
利用瞬发伽玛多普勒频移效应测量异质体模体内碳离子范围的评价
DOI：
10.1016/j.nima.2020.163439
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发表时间：
2020-04
影响因子：
1.4
通讯作者：
Altieri Saverio
中科院分区：
文献类型：
--
作者：
Geng Changran;Han Yang;Tang Xiaobin;Shu Diyun;Gong Chunhui;Altieri Saverio
碳离子治疗是一种先进的放射治疗方式，具有独特的剂量分布和高生物学效应。然而，由于碳离子治疗在布拉格峰附近的剂量分布陡峭，与传统的X射线放射治疗相比，碳离子治疗对射程的不确定性更加敏感，使其优势没有得到充分发挥。瞬发γ能谱是实现碳离子治疗射程验证的潜在选择之一。在本文中，我们描述了多普勒频移效应引起的PG（4.44 MeV）的能量移动所产生的飞（12）C* 的去激励，这使得PG光谱的距离验证的替代方法。为了证明该方法在患者治疗中应用的可行性，将Monte Carlo模拟与解析计算进行了比较，验证了不同材料和非均匀几何模型的准确性。将该方法应用于填充不同材料（聚乙烯、水和脂肪）的均质体模和具有两个不同照射位置（胸部和腹部）的中国混合辐射体模的距离测量。结果表明，三个均匀体模的误差小于2.1%。此外，当在两个照射位置使用中国混合辐射体模时，获得了良好的一致性。这些结果证明了该方法在更复杂的异构人体模型中的可行性。
Carbon ion therapy is an advanced radiation treatment modality considering its distinct dose distribution and high biological effectiveness. However, carbon ion therapy has become more sensitive to the range uncertainty comparing to the traditional x-ray radiotherapy because of its steep dose distribution near the Bragg peak, which makes the benefits not been fully utilized. Prompt gamma (PG) spectroscopy is one of the potential choices to achieve the range verification in carbon ion therapy. In this paper, we describe that the Doppler shift effect causes the energy shift of PG (4.44 MeV) produced by the de-excitation of the flying(12)C*, which makes PG spectroscopy an alternative method for range verification. In order to prove its feasibility of applying this method during patient treatment, Monte Carlo simulation and analytical calculation are compared to verify the accuracy with different materials and non-uniform geometry model. The proposed method is applied to range measurement in the homogeneous phantom filled with different materials (polyethylene, water, and adipose) and the Chinese hybrid radiation phantom with two different irradiated positions (chest and abdomen). Results show that the difference value is less than 2.1% for three homogeneous phantoms. Moreover, good conformance is obtained when using the Chinese hybrid radiation phantom in both irradiated positions. These results prove the feasibility of using the proposed method in a more complicated heterogeneous human model.
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影响因子：
3.5
作者：
Hueso-González F;Rabe M;Ruggieri TA;Bortfeld T;Verburg JM
通讯作者：
Verburg JM
影响因子：
2.9
作者：
Yang Han;Xiaobin Tang;C. Geng;Diyun Shu;Chunhui Gong;Xudong Zhang;Shaojuan Wu;Xinxin Zhang
通讯作者：
Yang Han;Xiaobin Tang;C. Geng;Diyun Shu;Chunhui Gong;Xudong Zhang;Shaojuan Wu;Xinxin Zhang
DOI：
10.1016/b978-1-4160-5897-7.00072-x
发表时间：
2010
期刊：
Nihon rinsho. Japanese journal of clinical medicine
影响因子：
--
作者：
G. Kasuya;H. Tsuji
通讯作者：
G. Kasuya;H. Tsuji
影响因子：
44.1
作者：
Schardt, Dieter;Elsaesser, Thilo;Schulz-Ertner, Daniela
通讯作者：
Schulz-Ertner, Daniela
DOI：
10.1088/1742-6596/1154/1/012015
发表时间：
2019-01
期刊：
Journal of Physics: Conference Series
影响因子：
--
作者：
S. Lehrack;W. Assmann;K. Parodi
通讯作者：
S. Lehrack;W. Assmann;K. Parodi