Two types of TATA elements for the CYC1 gene of the yeast Saccharomyces cerevisiae.
Two types of TATA elements for the CYC1 gene of the yeast Saccharomyces cerevisiae.
复制标题
酿酒酵母 CYC1 基因的两种 TATA 元件。
DOI：
10.1128/mcb.11.2.666-676.1991
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发表时间：
1991
影响因子：
5.3
通讯作者：
Sherman,F
中科院分区：
文献类型：
--
作者：
Li,WZ;Sherman,F
Functional TATA elements in the 5′ untranslated region of theCYC1gene in the yeastSaccharomyces cerevisiaehave been defined by transcriptional analysis of site-directed mutations. Five sites previously suggested to contain functional TATA elements were altered individually and in all possible combinations. The results indicated that only two elements are required for transcription at the normal level and the normal start sites. The two functional TATA elements are located at sites −178 and −123, where the A of the ATG start codon is assigned nucleotide position +1. They direct initiation within windows encompassing −70 to −46 and −46 to −28, respectively. Only when both of the upstream TATA sites were rendered nonfunctional were the third and fourth downstream TATA-like sequences activated, as indicated by the presence of low levels of transcription starting at −28. The two upstream functional TATA elements differed in sequence. The sequence of the most 5′ one at site 1, denoted β-type, was ATATATATAT, whereas that of the second one at site 2, denoted αtype, was TATATAAAA. The following rearrangements of the β-type and α-type elements at two sites (1 and 2) were examined: site1β-site2α; sitelα-site2β; site1α-site2α; and site1β-site2β. When different types were at different sites (site1β-site2α and site1α-site2β), both were used equally. In contrast, when the same type was present at both sites (site1α-site2α and site1β-site2β), only the upstream element was used. We suggest that the two TATA elements are recognized by different factors of the transcription apparatus.
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影响因子：
5.6
作者：
MCNEIL, JB;SMITH, M
通讯作者：
SMITH, M
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影响因子：
11.1
作者：
Guarente,L
通讯作者：
Guarente,L
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DOI：
--
发表时间：
1985
影响因子：
11.1
作者：
F. Nagawa;G. Fink
通讯作者：
G. Fink
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DOI：
--
发表时间：
2022
期刊：
影响因子：
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作者：
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影响因子：
5.3
作者：
E. Székely;D. Montgomery
通讯作者：
D. Montgomery