Postsynthetic modifications of iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery.
Postsynthetic modifications of iron-carboxylate nanoscale metal-organic frameworks for imaging and drug delivery.
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DOI：
10.1021/ja906198y
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发表时间：
2009-10-14
影响因子：
15
通讯作者：
Lin, Wenbin
中科院分区：
文献类型：
--
作者：
Taylor-Pashow, Kathryn M. L.;Della Rocca, Joseph;Xie, Zhigang;Tran, Sylvie;Lin, Wenbin
采用微波加热溶剂热技术合成了具有 MIL-101 结构的 Fe(III)-羧酸盐纳米级金属有机框架 (NMOF)。使用多种方法对约 200 nm 颗粒进行表征，包括 SEM、PXRD、氮吸附测量、TGA 和 EDX。通过用 2-氨基对苯二甲酸取代一定比例的桥配体（对苯二甲酸），胺基团被纳入框架中，为生物相关货物的共价连接提供位点，同时仍保持 MIL-101 结构。在概念验证实验中，通过对合成颗粒进行合成后修饰，将光学造影剂（BODIPY 染料）和乙氧基琥珀酸顺铂抗癌前药成功掺入 Fe(III)-羧酸盐 NMOF 中。这些货物在 NMOF 框架降解时释放，并且通过用二氧化硅壳涂覆 NMOF 颗粒来控制货物释放速率。使用 HT-29 人结肠腺癌细胞在体外证明了基于 NMOF 的新型纳米递送载体在光学成像和抗癌治疗方面的潜在效用。
Fe(III)-carboxylate nanoscale metal-organic frameworks (NMOFs) with the MIL-101 structure were synthesized using a solvothermal technique with microwave heating. The ~200 nm particles were characterized using a variety of methods, including SEM, PXRD, nitrogen adsorption measurements, TGA, and EDX. By replacing a percentage of the bridging ligand (terephthalic acid) with 2-amino terephthalic acid, amine groups were incorporated into the framework to provide sites for covalent attachment of biologically relevant cargoes while still maintaining the MIL-101 structure. In proof-of-concept experiments, an optical contrast agent (a BODIPY dye) and an ethoxysuccinato-cisplatin anticancer prodrug were successfully incorporated into the Fe(III)-carboxylate NMOFs via post-synthetic modifications of the as-synthesized particles. These cargoes are released upon the degradation of the NMOF frameworks, and the rate of cargo release was controlled by coating the NMOF particles with a silica shell. Potential utility of the new NMOF-based nano-delivery vehicles for optical imaging and anticancer therapy were demonstrated in vitro using HT-29 human colon adenocarcinoma cells.
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