Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications.
Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications.
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DOI：
10.1016/j.actbio.2013.07.031
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发表时间：
2014-04
影响因子：
9.7
通讯作者：
Kiick, Kristi L.
中科院分区：
文献类型：
--
作者：
Liang, Yingkai;Kiick, Kristi L.
肝素通过与各种蛋白质的相互作用在许多生物过程中发挥着重要作用，包含肝素的水凝胶和纳米颗粒表现出有吸引力的特性，例如抗凝活性、生长因子结合以及抗血管生成和细胞凋亡作用，使它们成为新兴应用的绝佳候选者。因此，本文综述了近年来肝素基水凝胶的制备和纳米粒子的形成，以及它们的性能和应用的表征的努力。肝素基材料的挑战和未来的前景进行了讨论。含肝素的高分子生物材料在从促进细胞分化的细胞载体到用于癌症治疗的纳米颗粒治疗剂的各种应用中具有广阔的前景。
Heparin plays an important role in many biological processes, via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties such as anticoagulant activity, growth factor binding, as well as antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment.
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影响因子：
10.8
作者：
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通讯作者：
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影响因子：
10.8
作者：
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通讯作者：
Zhong, Zhiyuan