QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects.
QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects.
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DOI：
10.1371/journal.pone.0098555
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Shimoda K
中科院分区：
文献类型：
--
作者：
Fujii K;Ozeki Y;Okayasu H;Takano Y;Shinozaki T;Hori H;Orui M;Horie M;Kunugi H;Shimoda K
钾电压门控通道 KCNH2 是一个众所周知的基因，该基因的突变会导致家族性 QT 间期延长。 KCNH2 被认为是精神分裂症的危险基因。此外，在精神分裂症中，自主控制紊乱会影响 QT 间期。因此，我们推测精神分裂症患者除了抗精神病药物的作用外，在QT间期方面也具有特征性特征。将未接受抗精神病药物的精神分裂症患者（n = 85）的QT间期与接受较大剂量抗精神病药物的精神分裂症患者（n = 85）和健康志愿者（n = 85）的QT间期进行比较。使用四种方法校正 QT 间期（Bazett、Fridericia、Framingham 或 Hodges 方法）。在以年龄和心率为协变量的 ANCOVA 中，未接受抗精神病药物治疗的患者的 QT 间期比健康志愿者更长，但无论使用何种校正方法，抗精神病药物都会延长 QT 间期（P<0.01）。服用或未服用药物的精神分裂症患者的平均心率显着高于健康志愿者，但 QT 间期没有明显的性别相关差异。 QT间期延长可能是精神分裂症某种生物学特征的表现。
The potassium voltage-gated channel KCNH2 is a well-known gene in which mutations induce familial QT interval prolongation. KCNH2 is suggested to be a risk gene for schizophrenia. Additionally, the disturbance of autonomic control, which affects the QT interval, is known in schizophrenia. Therefore, we speculate that schizophrenic patients have characteristic features in terms of the QT interval in addition to the effect of antipsychotic medication. The QT interval of patients with schizophrenia not receiving antipsychotics (n = 85) was compared with that of patients with schizophrenia receiving relatively large doses of antipsychotics (n = 85) and healthy volunteers (n = 85). The QT interval was corrected using four methods (Bazett, Fridericia, Framingham or Hodges method). In ANCOVA with age and heart rate as covariates, patients not receiving antipsychotic treatment had longer QT intervals than did the healthy volunteers, but antipsychotics prolonged the QT interval regardless of the correction method used (P<0.01). Schizophrenic patients with and without medication had a significantly higher mean heart rate than did the healthy volunteers, with no obvious sex-related differences in the QT interval. The QT interval prolongation may be manifestation of a certain biological feature of schizophrenia.
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