New insights into signalling-pathway alterations in rhabdomyosarcoma.

New insights into signalling-pathway alterations in rhabdomyosarcoma.
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DOI:
10.1038/bjc.2014.471
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发表时间:
2015-01-20
影响因子:
8.8
通讯作者:
Davie, J. K.
Davie, J. K.
中科院分区:
医学1区
文献类型:
--
作者:
Zhu, B.;Davie, J. K.
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横纹肌肉瘤(RMS)是儿童和年轻人最常见的软组织肉瘤。最近的几项研究揭示了信号通路的改变以及这些通路改变在RMS中的下游效应。许多这些影响集中在成纤维细胞生长因子和胰岛素样生长因子途径。这些新发现提高了目前对RMS的理解,从而提供了新的潜在治疗靶点和策略,可能会改善RMS患者的结局。
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and young adults. Several recent studies have shed new light on the alterations in signalling pathways and the downstream effects of these pathway alterations in RMS. Many of these effects converge on the fibroblast growth factor and insulin-like growth-factor pathways. These new findings improve the current understanding of RMS, thus offering novel potential therapeutic targets and strategies that may improve the outcome for patients with RMS.
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