Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.
Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging.
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动态 mRNA 降解组分析表明组蛋白 H3K4 三甲基化与卵母细胞衰老中减数分裂耦合 mRNA 衰减相关
DOI：
10.1038/s41467-022-30928-x
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发表时间：
2022-06-09
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
A decrease in oocyte developmental potential is a major obstacle for successful pregnancy in women of advanced age. However, the age-related epigenetic modifications associated with dynamic transcriptome changes, particularly meiotic maturation-coupled mRNA clearance, have not been adequately characterized in human oocytes. This study demonstrates a decreased storage of transcripts encoding key factors regulating the maternal mRNA degradome in fully grown oocytes of women of advanced age. A similar defect in meiotic maturation-triggered mRNA clearance is also detected in aged mouse oocytes. Mechanistically, the epigenetic and cytoplasmic aspects of oocyte maturation are synchronized in both the normal development and aging processes. The level of histone H3K4 trimethylation (H3K4me3) is high in fully grown mouse and human oocytes derived from young females but decreased during aging due to the decreased expression of epigenetic factors responsible for H3K4me3 accumulation. Oocyte-specific knockout of the gene encoding CxxC-finger protein 1 (CXXC1), a DNA-binding subunit of SETD1 methyltransferase, causes ooplasm changes associated with accelerated aging and impaired maternal mRNA translation and degradation. These results suggest that a network of CXXC1-maintained H3K4me3, in association with mRNA decay competence, sets a timer for oocyte deterioration and plays a role in oocyte aging in both mouse and human oocytes.
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影响因子：
4.8
作者：
Lee, JH;Skalnik, DG
通讯作者：
Skalnik, DG
DOI：
10.1093/humrep/deaa300
发表时间：
2021-02-18
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Al-Zubaidi U;Adhikari D;Cinar O;Zhang QH;Yuen WS;Murphy MP;Rombauts L;Robker RL;Carroll J
通讯作者：
Carroll J
ZAR1 和 ZAR2 通过调节母体转录组和 mRNA 翻译激活，是卵母细胞减数分裂成熟所必需的
影响因子：
14.9
作者：
Rong, Yan;Ji, Shu-Yan;Fan, Heng-Yu
通讯作者：
Fan, Heng-Yu
影响因子：
5.8
作者：
Pasternak M;Pfender S;Santhanam B;Schuh M
通讯作者：
Schuh M
影响因子：
7.8
作者：
Llonch S;Barragán M;Nieto P;Mallol A;Elosua-Bayes M;Lorden P;Ruiz S;Zambelli F;Heyn H;Vassena R;Payer B
通讯作者：
Payer B