Adverse reactions to the first and second doses of Pfizer-BioNTech COVID-19 vaccine among healthcare workers.
Adverse reactions to the first and second doses of Pfizer-BioNTech COVID-19 vaccine among healthcare workers.
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DOI：
10.1016/j.jiac.2022.03.015
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发表时间：
2022-07
期刊：
影响因子：
--
通讯作者：
Katoh N
中科院分区：
文献类型：
--
作者：
Maruyama A;Sawa T;Teramukai S;Katoh N
在当前的2019冠状病毒感染（COVID-19）大流行中，信使RNA疫苗已被证明有助于保护高危人群免受COVID-19的影响。在接种了辉瑞-BioNTech COVID-19疫苗的医护人员中，进行了一项调查，以分析接种后不良反应的发生率和严重程度之间的关系。我们对日本接种辉瑞-BioNTech COVID-19疫苗（Comirnaty®）的医护人员进行了一项前瞻性自我报告的不良反应调查。在第一剂和第二剂疫苗接种后，志愿者参与者使用网站报告了疫苗接种后8天的局部和全身反应。接种疫苗后，374名受访者参加了这项配对研究。第二剂疫苗接种后不良反应的发生率和严重程度均高于第一剂疫苗接种后。然而，在第一次和第二次给药后，肌肉和皮肤疼痛的发生率和数字评定量表（NRS）评分几乎相同。在按性别进行的比较中，女性的不良反应（如头痛、皮肤疼痛、红斑和瘙痒）发生率和NRS评分显著较高。结果还显示，与老年组相比，除肌肉疼痛外，年轻组的所有不良反应发生率和NRS评分均较高。辉瑞-BioNTech Comirnaty® COVID-19疫苗的一些不良反应存在性别和年龄差异。一般来说，所有的副作用都会在一周内消失。因此，这些副作用不是推荐接种疫苗的重要问题。
In the current coronavirus infection 2019 (COVID-19) pandemic, the messenger RNA vaccines have been shown to help protect high-risk groups from COVID-19. Among healthcare workers vaccinated with Pfizer-BioNTech COVID-19 vaccine, a survey was conducted to analyze the relationship between the incidence and severity of adverse reactions after vaccination. We conducted a prospective self-reported survey of adverse reactions among healthcare workers vaccinated with the Pfizer-BioNTech COVID-19 vaccine (Comirnaty®) in Japan. After the first and second dose of vaccine, local and systemic reactions for 8 days after vaccination were reported by volunteer participants using a website. After receiving vaccination, 374 respondents participated in this matched-pair study. Both the incidence and severity of adverse reactions tended to be higher after the second vaccine dose than after the first dose. However, the incidence and numeric rating scale (NRS) score of muscle and skin pain were nearly the same after the first and second doses. In a comparison by sex, women had significantly higher incidence and NRS scores for adverse reactions such as headache, skin pain, erythema, and itching. The results also showed that younger age groups had higher incidence rates and NRS scores for all adverse reactions investigated, except for muscle pain, compared with older age groups. Some adverse reactions to the Pfizer-BioNTech Comirnaty® COVID-19 vaccine showed gender and age differences. However, generally speaking, all side reactions disappear within a week. Therefore, these side reactions are not a significant concern in recommending vaccination.
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影响因子：
7.8
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DOI：
10.15585/mmwr.mm7038e1
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10.1016/j.jiac.2021.09.009
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影响因子：
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10.1136/ejhpharm-2021-002933
发表时间：
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期刊：
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