Clinicopathological characteristics and survival outcomes of male breast cancer according to race: A SEER population-based study.
Clinicopathological characteristics and survival outcomes of male breast cancer according to race: A SEER population-based study.
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不同种族男性乳腺癌的临床病理学特征和生存结果：一项基于 SEER 人群的研究
DOI：
10.18632/oncotarget.18265
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发表时间：
2017-09-19
期刊：
影响因子：
--
通讯作者：
Jin W
中科院分区：
文献类型：
--
作者：
Sun HF;Zhao Y;Gao SP;Li LD;Fu WY;Jiang HL;Chen MT;Yang LP;Jin W
为了研究男性人群中乳腺癌的临床病理学特征和生存结局，在监测、流行病学和最终结果（SEER）数据库中确定了8，607例患者，包括白色男性（n = 7122）、黑人男性（n = 1111）和其他男性（美洲印第安人/AK原住民、亚洲人/太平洋岛民）（n = 374）。黑人男性乳腺癌患者更有可能处于II-IV期，并且肿瘤更晚期。诊断时淋巴结（LN）受累率黑人男性高于白人和其他人群。黑人男性的ER和PR阳性率低于白人和其他人。远处转移率黑人高于白人及其他人群。此外，黑人的总生存率（OR）和乳腺癌特异性生存率明显低于白人和其他人群（χ2 = 29.974，P < 0.001;分别为χ2 = 7.285，P = 0.026）。在多因素分析中，结果显示种族也可以作为预后指标（P < 0.001）。1：1：1匹配的白色、黑人和其他组之间的OS也有显著性差异（P < 0.001）。3组间肿瘤分级、LN状态、ER和PR状态的差异可能部分解释了结局的差异。这项研究可能会为更好地了解男性乳腺癌提供见解。
To investigate the clinicopathological characteristics and survival outcomes of breast cancer in the male population, 8,607 cases of patients were identified in the Surveillance, Epidemiology, and End Results (SEER) database, including white males (n = 7122), black males (n = 1111), and other males (American Indian/AK Native, Asian/Pacific Islander) (n = 374). Black male breast cancer patients were more likely to be in stages II–IV and have more advanced tumors. The rate of lymph node (LN) involvement at diagnosis was higher in black men than in whites and others. The ER- and PR-positive rates were lower in black men than in whites and others. The distant metastasis rate was higher in blacks than in whites and others. Furthermore, the overall survival (OR) rates and breast cancer-specific survival rates were significantly poorer in blacks than in whites and others (χ2 = 29.974, P < 0.001; χ2 = 7.285, P = 0.026, respectively). In a multivariate analysis, the results showed that race could also be a prognostic indicator (P < 0.001). Moreover, significant differences were also observed in OS among 1:1:1 matched white, black, and other groups (P < 0.001). Differences in outcomes may be partially explained by differences in tumor grades, LN status, and ER and PR status between the 3 groups. This study might provide insights into a better understanding of male breast cancer.
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影响因子：
2.1
作者：
Parise, Carol A.;Bauer, Katrina R.;Caggiano, Vincent
通讯作者：
Caggiano, Vincent
影响因子：
2.3
作者：
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Byrne, Margaret M.
影响因子：
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作者：
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Jemal, Ahmedin
影响因子：
2.6
作者：
RIBEIRO, GG
通讯作者：
RIBEIRO, GG
影响因子：
6.4
作者：
Ly, Diana;Forman, David;Ferlay, Jacques;Brinton, Louise A.;Cook, Michael B.
通讯作者：
Cook, Michael B.