Epilepsy after head injury in dogs: A natural model of posttraumatic epilepsy
Epilepsy after head injury in dogs: A natural model of posttraumatic epilepsy
复制标题
狗头部受伤后的癫痫：创伤后癫痫的自然模型
作者：
Steinmetz S;Tipold A;W Löscher:
目的在人类中，创伤性脑损伤 (TBI) 是获得性（症状性）癫痫的最常见原因之一，但迄今为止，尚无治疗方法可以预防 TBI 后癫痫的发展。创伤后癫痫 (PTE) 动物模型对于表征 TBI 的致癫痫机制和确定临床有效的抗癫痫治疗非常重要。自然发生的犬癫痫的患病率和现象学与人类癫痫相似。然而，尚未对狗进行 TBI 后癫痫的风险进行系统研究。因此，我们对转诊至我们临床部门的 1,000 只狗进行了一项为期 11.5 年的大型回顾性研究，目的是确定该物种头部外伤后早期和晚期癫痫发作的发生率。方法使用了两种策略：在第一组 (n = 392) 中，我们评估转诊治疗头部外伤（Ia 组）或其他外伤（Ib 组）的狗是否在外伤后发生癫痫发作，而在第二组中(n = 608) 我们评估了转诊治疗复发性癫痫发作的狗是否有头部外伤史。这项研究的数据来自我们的临床数据库、发送给狗主人的问卷以及主人访谈。 主要发现在 Ia 组中，6.6% 的狗出现 PTE，与 Ib 组（1.9%）显着不同，表明头部外伤使患癫痫的风险增加了 3.4 倍。 PTE 的风险随着 TBI 的严重程度而增加； 14.3% 颅骨骨折的狗出现 PTE。在第 II 组中，15.5% 的癫痫犬有头部外伤史，明显高于第 Ia 组确定的 PTE 发生率。意义我们的研究表明，犬的头部外伤与发生癫痫的显着风险相关。因此，患有严重TBI的狗是一种有趣的PTE自然模型，为人类PTE的研究提供了一个新颖的转化平台。
PurposeIn humans, traumatic brain injury (TBI) is one of the most common causes of acquired (symptomatic) epilepsy, but as yet there is no treatment to prevent the development of epilepsy after TBI. Animal models of posttraumatic epilepsy (PTE) are important to characterize epileptogenic mechanisms of TBI and to identify clinically effective antiepileptogenic treatments. The prevalence and phenomenology of naturally occurring canine epilepsy are similar to those in human epilepsy. However, the risk of epilepsy after TBI has not been systemically studied in dogs. We therefore performed a large retrospective study in 1,000 dogs referred to our clinical department over a period of 11.5 years with the aim to determine the incidence of early and late seizures after head trauma in this species.MethodsTwo strategies were used: in group I (n = 392), we evaluated whether dogs referred for the treatment of a head trauma (group Ia) or other trauma (group Ib) developed seizures after the trauma, whereas in group II (n = 608) we evaluated whether dogs referred for the treatment of recurrent epileptic seizures had a history of head trauma. Data for this study were obtained from our clinical database, questionnaires sent to the dogs' owners, and owner interviews.Key FindingsIn group Ia, 6.6% of the dogs developed PTE, which was significantly different from group Ib (1.9%), indicating that head trauma increased the risk of developing epilepsy by a factor of 3.4. The risk of PTE increased with severity of TBI; 14.3% of the dogs with skull fracture developed PTE. In group II, 15.5% of the dogs with epilepsy had a history of head injury, which was significantly higher than the incidence of PTE determined for group Ia.SignificanceOur study indicates that head trauma in dogs is associated with a significant risk of developing epilepsy. Therefore, dogs with severe TBI are an interesting natural model of PTE that provides a novel translational platform for studies on human PTE.
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影响因子：
2.4
作者：
H. Gastaut;B. Zifkin
通讯作者：
B. Zifkin
影响因子：
8.9
作者：
Annegers, JF;Rocca, WA;Hauser, WA
通讯作者：
Hauser, WA
DOI：
10.1016/s0195-5616(96)50105-1
发表时间：
1996-07-01
影响因子：
1.9
作者：
Podell, M
通讯作者：
Podell, M
狗模型在开发人类健康基因治疗策略中的作用
影响因子：
2.5
作者：
K. L. Nowend;A. N. Starr;K. Murphy
通讯作者：
K. Murphy
影响因子：
2.2
作者：
A. Palmer
通讯作者：
A. Palmer