Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics.
Dissecting the Neural Circuitry for Pain Modulation and Chronic Pain: Insights from Optogenetics.
复制标题
剖析疼痛调节和慢性疼痛的神经回路：光遗传学的见解
DOI：
10.1007/s12264-022-00835-8
复制
发表时间：
2022-04
影响因子：
5.6
通讯作者：
Zhang, Shi-Hong
中科院分区：
文献类型：
--
作者：
Guo, Fang;Du, Yu;Qu, Feng-Hui;Lin, Shi-Da;Chen, Zhong;Zhang, Shi-Hong
疼痛是与实际或潜在的组织损伤相关或类似的不愉快的感觉和情感体验。疼痛的处理涉及外周、脊髓和大脑水平的复杂调节。慢性疼痛的发病机制尚未完全清楚，这使得临床治疗具有挑战性。光遗传学结合了光学和遗传技术，可以精确地干预特定神经元组和相关电路元件的活动。利用光遗传学，研究人员已经取得了一系列新的发现，这些发现揭示了外周和中枢神经系统中疼痛传递、疼痛调制和慢性疼痛的细胞和电路机制。本文就近年来光遗传学在疼痛研究中的应用进行综述，并讨论其在慢性疼痛发病机制研究中的意义。
Pain is an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. The processing of pain involves complicated modulation at the levels of the periphery, spinal cord, and brain. The pathogenesis of chronic pain is still not fully understood, which makes the clinical treatment challenging. Optogenetics, which combines optical and genetic technologies, can precisely intervene in the activity of specific groups of neurons and elements of the related circuits. Taking advantage of optogenetics, researchers have achieved a body of new findings that shed light on the cellular and circuit mechanisms of pain transmission, pain modulation, and chronic pain both in the periphery and the central nervous system. In this review, we summarize recent findings in pain research using optogenetic approaches and discuss their significance in understanding the pathogenesis of chronic pain.
登录
查看更多内容
影响因子：
64.5
作者：
Duan B;Cheng L;Bourane S;Britz O;Padilla C;Garcia-Campmany L;Krashes M;Knowlton W;Velasquez T;Ren X;Ross S;Lowell BB;Wang Y;Goulding M;Ma Q
通讯作者：
Ma Q
影响因子：
3.7
作者：
Gu L;Uhelski ML;Anand S;Romero-Ortega M;Kim YT;Fuchs PN;Mohanty SK
通讯作者：
Mohanty SK
影响因子：
3.1
作者：
Elina, K. C.;Moon, Hyeong Cheol;Park, Young Seok
通讯作者：
Park, Young Seok
影响因子：
3.4
作者：
Chen Q;Roeder Z;Li MH;Zhang Y;Ingram SL;Heinricher MM
通讯作者：
Heinricher MM
影响因子：
3.6
作者：
Gadotti, Vinicius M.;Zhang, Zizhen;Zamponi, Gerald W.
通讯作者：
Zamponi, Gerald W.