Antibacterial studies of cationic polymers with alternating, random, and uniform backbones.
Antibacterial studies of cationic polymers with alternating, random, and uniform backbones.
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DOI：
10.1021/cb100413w
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发表时间：
2011-06-17
影响因子：
4
通讯作者：
Sampson, Nicole S.
中科院分区：
文献类型：
--
作者：
Song, Airong;Walker, Stephen G.;Parker, Kathlyn A.;Sampson, Nicole S.
抗菌聚合物具有作为药物和作为植入装置的涂层的潜力。这些材料的设计将被优化，当我们有一个完整的理解的结构特征，赋予活性对靶生物和那些是良性的哺乳动物宿主。在这项工作中，四个系列的聚合物，其中阳离子和疏水基团分布沿着骨干进行了测试，对六种不同的细菌物种（革兰氏阳性和革兰氏阴性）和宿主细胞毒性（红细胞裂解）。所研究的最有效的聚合物是规则间隔的，其特征是沿着呈现带正电荷基团的侧链之间的主链沿着6-8个碳延伸。它们引起钾外流，扰乱细菌细胞质膜，并破坏膜电位。这些聚合物可从交替开环易位聚合（AROMP）获得，为抗菌聚合物中规则间距的重要性以及基于规则间距支架的额外功能材料的合成提供了原理证明。
Antibacterial polymers have potential as pharmaceuticals and as coatings for implantation devices. The design of these materials will be optimized when we have a complete understanding of the structural features that impart activity toward target organisms and those that are benign with respect to the mammalian host. In this work, four series of polymers in which cationic and hydrophobic groups were distributed along the backbone were tested against six different bacterial species (both Gram positive and Gram negative) and for host cytotoxicities (red blood cell lysis). The most effective of the polymers studied are regularly spaced, featuring a 6–8 carbon stretch along the backbone between side chains that present positively charged groups. They cause potassium efflux, disorder the bacterial cytoplasmic membrane, and disrupt the membrane potential. These polymers, available from alternating ring opening metathesis polymerization (AROMP), offer proof of principle for the importance of regular spacing in antibacterial polymers and for the synthesis of additional functional materials based on regularly spaced scaffolds.
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