Calcitriol therapy and calcium-regulated PTH secretion in patients with secondary hyperparathyroidism.
Calcitriol therapy and calcium-regulated PTH secretion in patients with secondary hyperparathyroidism.
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继发性甲状旁腺功能亢进症患者的骨化三醇治疗和钙调节 PTH 分泌。
DOI：
10.1152/ajpendo.1994.267.6.e961
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Salusky,IB
中科院分区：
文献类型：
--
作者：
Ramirez,JA;Goodman,WG;Belin,TR;Gales,B;Segre,GV;Salusky,IB
骨化三醇可降低继发性甲状旁腺功能亢进患者的血清甲状旁腺激素（PTH）水平，但其对钙调节的PTH释放的影响仍存在争议。因此，11例继发性甲状旁腺功能亢进的患者在骨化三醇间歇治疗4个月前后进行了甲状旁腺功能的动态测试。血清骨化三醇水平从8 +/- 1上升到55 +/- 9（SE）pg/ml，P < 0.01，血清总钙和离子钙水平升高，血清PTH水平从584 +/- 154下降到154 +/- 31 pg/ml，P < 0.05。低钙血症期间血清PTH的最大增加在治疗前（248 +/- 78 pg/ml）或治疗后（280 +/- 100 pg/ml）没有差异，但PTH的增加，以输注前值的百分比表示，在治疗后更大（329 +/- 73 vs. 132 +/-10%，P < 0.05）。钙输注期间血清PTH的降低在治疗前（70 +/- 5%）或治疗后（73 +/- 5%）没有差异，PTH释放的设定点没有变化（1.20 +/- 0.03 vs. 1.23 +/- 0.01 mmol/l，不显著）。骨化三醇改变继发性甲状旁腺功能亢进症患者低钙血症时的PTH分泌，而不影响PTH释放的设定点;虽然骨化三醇降低血清PTH水平，但它也可以恢复低钙血症时增生性甲状旁腺组织的分泌储备。
Calcitriol lowers serum parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism, but its effect on calcium-regulated PTH release remains controversial. Thus 11 patients with secondary hyperparathyroidism underwent dynamic tests of parathyroid function before and after 4 mo of intermittent calcitriol therapy. Serum calcitriol levels rose from 8 +/- 1 to 55 +/- 9 (SE) pg/ml, P < 0.01, serum total and ionized calcium levels increased, and serum PTH levels decreased from 584 +/- 154 to 154 +/- 31 pg/ml, P < 0.05. The maximum increase in serum PTH during hypocalcemia did not differ before (248 +/- 78 pg/ml) or after (280 +/- 100 pg/ml) treatment, but the increase in PTH, expressed as a percentage of preinfusion values, was greater after treatment (329 +/- 73 vs. 132 +/- 10%, P < 0.05). The decreases in serum PTH during calcium infusions did not differ before (70 +/- 5%) or after (73 +/- 5%) therapy, and the set point for PTH release did not change (1.20 +/- 0.03 vs. 1.23 +/- 0.01 mmol/l, not significant). Calcitriol modifies PTH secretion during hypocalcemia in secondary hyperparathyroidism without affecting the set point for PTH release; although calcitriol lowers serum PTH levels, it may also restore the secretory reserve of hyperplastic parathyroid tissues during hypocalcemia.
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影响因子：
19.6
作者：
SUGIMOTO, T;RITTER, C;SLATOPOLSKY, E
通讯作者：
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影响因子：
13.2
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
5.9
作者：
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通讯作者：
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影响因子：
1.7
作者：
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通讯作者：
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