Prevalence of Tourette syndrome and chronic tics in the population-based Avon longitudinal study of parents and children cohort.
Prevalence of Tourette syndrome and chronic tics in the population-based Avon longitudinal study of parents and children cohort.
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DOI：
10.1016/j.jaac.2011.11.004
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发表时间：
2012-02
影响因子：
13.3
通讯作者：
Ben-Shlomo Y
中科院分区：
文献类型：
--
作者：
Scharf JM;Miller LL;Mathews CA;Ben-Shlomo Y
最近的流行病学研究表明，抽动秽语综合征（TS）和慢性抽动障碍（CT）比以前认识的更常见。然而，很少有基于人群的研究检查了共同发生的神经精神疾病，如强迫症（OCD）和注意力缺陷多动障碍（ADHD）的患病率。我们在雅芳父母和儿童纵向研究（ALSPAC）出生队列中评估了TS、CT的患病率及其与强迫症和多动症的重叠。共有6，768名儿童使用母亲完成的问卷调查的纵向数据进行了评估。TS和CT的DSM-IV-TR诊断使用三个诊断严格性水平（窄、中和宽）来推导。病例定义的有效性通过异质性分析比较强迫症和注意缺陷多动障碍的性别比例和并发率进行评估。13岁TS（窄型为0.3%;中间型为0.7%）和CT（窄型为0.5%;中间型为1.1%）的患病率与其他基于人群的研究的患病率一致。与对照组相比，TS和CT窄和中间组中合并发生的OCD和ADHD的发生率较高，但低于以前的报道。只有8.2%的TS中间病例同时患有强迫症和ADHD; 69%的TS中间病例没有同时发生的强迫症或ADHD。这项研究表明，共同发生的强迫症和多动症是显着低于TS案件来自人口为基础的样本比已报告的临床确诊TS案件。进一步研究以人群为基础的TS样本中共同发生的神经精神疾病的范围，可能会对这三种神经发育状况的潜在共同病理生理学产生新的看法。
Recent epidemiologic studies have demonstrated that Tourette syndrome (TS) and chronic tic disorder (CT) are more common than previously recognized. However, few population-based studies have examined the prevalence of co-occurring neuropsychiatric conditions such as obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD). We evaluated the prevalence of TS, CT, and their overlap with OCD and ADHD in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. A total of 6,768 children were evaluated using longitudinal data from mother-completed questionnaires. DSM-IV-TR diagnoses of TS and CT were derived using three levels of diagnostic stringency (Narrow, Intermediate, and Broad). Validity of the case definitions was assessed by comparing gender ratios and rates of co-occurring OCD and ADHD using heterogeneity analyses. Age 13 prevalence rates for TS (0.3% for Narrow; 0.7% for Intermediate) and CT (0.5% for Narrow; 1.1% for Intermediate) were consistent with rates from other population-based studies. Rates of co-occurring OCD and ADHD were higher in TS and CT Narrow and Intermediate groups compared with controls but lower than has been previously reported. Only 8.2% of TS Intermediate cases had both OCD and ADHD; 69% of TS Intermediate cases did not have either co-occurring OCD or ADHD. This study suggests that co-occurring OCD and ADHD is markedly lower in TS cases derived from population-based samples than has been reported in clinically ascertained TS cases. Further examination of the range of co-occurring neuropsychiatric disorders in population-based TS samples may shed new perspective on the underlying shared pathophysiology of these three neurodevelopmental conditions.
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DOI：
10.1097/00004583-200005000-00007
发表时间：
2000-05-01
影响因子：
13.3
作者：
Kadesjö, B;Gillberg, C
通讯作者：
Gillberg, C
影响因子：
--
作者：
Bloch, Michael H;Peterson, Bradley S;Leckman, James F
通讯作者：
Leckman, James F
影响因子：
3.8
作者：
Freeman, RD;Fast, DG;Sandor, P
通讯作者：
Sandor, P
影响因子：
9.9
作者：
Kurlan, R;McDermott, MP;Miller, B
通讯作者：
Miller, B
影响因子：
3.8
作者：
Khalifa, N;von Knorring, AL
通讯作者：
von Knorring, AL