Radiosurgery for epilepsy: clinical experience and potential antiepileptic mechanisms.

Radiosurgery for epilepsy: clinical experience and potential antiepileptic mechanisms.
复制标题

DOI:
10.1111/j.1528-1167.2011.03339.x
复制
发表时间:
2012-01
期刊:
影响因子:
5.6
通讯作者:
Barbaro NM
Barbaro NM
中科院分区:
医学1区
文献类型:
--
作者:
Quigg M;Rolston J;Barbaro NM

文献摘要

参考文献

被引文献

相似文献

立体定向放射外科是一种治疗局灶性癫痫病灶的新兴技术,已在难以通过开放手术进入的局灶性病灶的非侵入性治疗中确立。最近的研究表明,下丘脑错构瘤和内侧颞叶癫痫的癫痫发作在放射外科治疗中的缓解率具有临床意义,但不同研究之间的巨大差异引发了关于适当治疗方案和机制的问题。提出的抗惊厥机制包括神经调节作用或癫痫组织的缺血性坏死。一项正在进行的试验,直接比较疗效,发病率和成本的放射手术与开放手术治疗内侧颞叶癫痫正在进行中。
Stereotactic radiosurgery, well established in the noninvasive treatment of focal lesions that are otherwise difficult to access through open surgery, is an emerging technology in the treatment of focal epileptic lesions. Recent studies suggest that seizures from hypothalamic hamartomas and mesial temporal lobe epilepsy remit at clinically significant rates with radiosurgery, but large variations among different studies have raised questions about appropriate treatment protocols and mechanisms. Proposed anticonvulsant mechanisms include neuromodulatory effects or ischemic necrosis of epileptic tissue. An ongoing trial that directly compares efficacy, morbidities, and cost of radiosurgery versus open surgery for mesial temporal lobe epilepsy is underway.
DOI: 10.3171/jns.2001.94.2.0270
发表时间: 2001-02-01
影响因子: 4.1
作者:
Chen, ZF;Kamiryo, T;Lee, KS
通讯作者: Lee, KS
DOI: 10.1212/wnl.0b013e3181c9185d
发表时间: 2010-01-12
期刊: NEUROLOGY
影响因子: 9.9
作者:
Chang, E. F.;Quigg, M.;Barbaro, N. M.
通讯作者: Barbaro, N. M.
DOI: 10.1159/000099532
发表时间: 1989-01-01
影响因子: 1.7
作者:
HEIKKINEN, ER;KONNOV, B;PAK, VA
通讯作者: PAK, VA
DOI: 10.1002/ana.10692
发表时间: 2003-10-01
影响因子: 11.2
作者:
Helmstaedter, C;Kurthen, M;Elger, CE
通讯作者: Elger, CE
DOI: 10.3171/jns.2002.97.5.1131
发表时间: 2002-11-01
影响因子: 4.1
作者:
Clusmann, H;Schramm, J;Elger, CE
通讯作者: Elger, CE