Maternal buffering of human amygdala-prefrontal circuitry during childhood but not during adolescence.
Maternal buffering of human amygdala-prefrontal circuitry during childhood but not during adolescence.
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DOI：
10.1177/0956797614550878
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发表时间：
2014-11
影响因子：
8.2
通讯作者：
Tottenham N
中科院分区：
文献类型：
--
作者：
Gee DG;Gabard-Durnam L;Telzer EH;Humphreys KL;Goff B;Shapiro M;Flannery J;Lumian DS;Fareri DS;Caldera C;Tottenham N
成熟的杏仁核-前额叶回路在成年期调节情感，但显示出延长的发展。在（半）进化物种中，当缺乏成熟的神经回路时，照顾者提供了有效的情感调节。本研究探讨了一个潜在的机制，通过照顾者提供监管的影响，在童年。儿童，而不是青少年，表现出母亲缓冲的证据，这样，母亲的刺激抑制杏仁核的反应。在没有母亲刺激的情况下，儿童表现出不成熟的杏仁核-前额叶连接。然而，在母亲刺激的存在下，儿童表现出类似于青少年的连接成熟的连接。在母亲在场的情况下，孩子们表现出更好的情感相关调节。出现了个体差异，与母亲的影响杏仁前额叶回路与更强的母子关系和母亲的行为调节调制。这些发现表明，通过一种神经机制，照顾者通过诱导成熟的连接和缓冲对高度反应来调节儿童的监管行为。母亲缓冲在儿童期，而不是青春期，表明儿童可能是一个敏感时期的杏仁核-前额叶发育。
Mature amygdala-prefrontal circuitry regulates affect in adulthood, but shows protracted development. In (semi-)altricial species, caregivers provide potent affect regulation when mature neurocircuitry is absent. This investigation examined a potential mechanism through which caregivers provide regulatory influences in childhood. Children, but not adolescents, showed evidence of maternal buffering, such that maternal stimuli suppressed amygdala reactivity. In the absence of maternal stimuli, children exhibited immature amygdala-prefrontal connectivity. However, in the presence of maternal stimuli, children displayed mature-like connectivity that resembled adolescents’ connectivity. Children showed improved affect-related regulation in the presence of their mother. Individual differences emerged, with maternal influence on amygdalaprefrontal circuitry associated with stronger mother-child relationships and maternal modulation of behavioral regulation. These findings suggest a neural mechanism through which caregivers modulate children's regulatory behavior by inducing mature-like connectivity and buffering against heightened reactivity. Maternal buffering in childhood, but not adolescence, suggests that childhood may be a sensitive period for amygdala-prefrontal development.
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DOI：
10.1073/pnas.95.9.5335
发表时间：
1998-04-28
影响因子：
11.1
作者：
Caldji, C;Tannenbaum, B;Meaney, MJ
通讯作者：
Meaney, MJ
影响因子：
56.9
作者：
DAVIDSON, RJ;FOX, NA
通讯作者：
FOX, NA
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim
影响因子：
1.9
作者：
BAYART, F;HAYASHI, KT;LEVINE, S
通讯作者：
LEVINE, S
影响因子：
1.7
作者：
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Gabrieli, JDE