Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise.
Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise.
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协调的代谢反应有助于妊娠和运动中的心脏增长。
DOI：
10.1007/s11897-023-00622-0
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发表时间：
2023-10
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妊娠和运动是全身性应激源，可促进心脏的生理生长，以应对重复性容量超负荷和维持心输出量。这种类型的重塑与病理性肥大不同，涉及促进生长的不同代谢机制;然而，目前尚不清楚心脏中的代谢变化如何促进生长，以及这些过程是否在妊娠和运动诱导的心脏生长中相似。心脏代谢大量底物的能力平衡心脏对能量供应和舒张的需求。在怀孕期间，激素状态与心脏葡萄糖氧化减少的协调对于生理生长似乎很重要。在运动过程中，心脏葡萄糖氧化的减少对生理生长也很重要，这可以促进葡萄糖衍生的碳穿梭进入生物合成途径以促进生长。了解生理性心脏生长的代谢基础可以为优化心血管健康和预防有害的重塑提供见解，例如产后心肌病和心力衰竭。这篇简短的综述强调了已知的促进妊娠诱导和运动诱导心脏生长的代谢机制，这两者都需要心脏葡萄糖代谢的变化来促进生长。此外，我们提到了重要的相似性和差异，在这些模型中的生理心脏生长，以及讨论目前的局限性，我们的理解代谢变化，促进增长。
Pregnancy and exercise are systemic stressors that promote physiological growth of the heart in response to repetitive volume overload and maintenance of cardiac output. This type of remodeling is distinct from pathological hypertrophy and involves different metabolic mechanisms that facilitate growth; however, it remains unclear how metabolic changes in the heart facilitate growth and if these processes are similar in both pregnancy- and exercise-induced cardiac growth. The ability of the heart to metabolize a myriad of substrates balances cardiac demands for energy provision and anabolism. During pregnancy, coordination of hormonal status with cardiac reductions in glucose oxidation appears important for physiological growth. During exercise, a reduction in cardiac glucose oxidation also appears important for physiological growth, which could facilitate shuttling of glucose-derived carbons into biosynthetic pathways for growth. Understanding the metabolic underpinnings of physiological cardiac growth could provide insight to optimize cardiovascular health and prevent deleterious remodeling, such as that which occurs from postpartum cardiomyopathy and heart failure. This short review highlights the metabolic mechanisms known to facilitate pregnancy-induced and exercise-induced cardiac growth, both of which require changes in cardiac glucose metabolism for the promotion of growth. In addition, we mention important similarities and differences of physiological cardiac growth in these models as well as discuss current limitations in our understanding of metabolic changes that facilitate growth.
DOI：
10.1186/s40748-017-0072-y
发表时间：
2018
期刊：
Maternal health, neonatology and perinatology
影响因子：
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作者：
Owusu Darkwa E;Djagbletey R;Sottie D;Owoo C;Vanderpuye NM;Essuman R;Aryee G
通讯作者：
Aryee G