CD4(+) T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes.
CD4(+) T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes.
复制标题
DOI：
10.1155/2016/5393894
复制
发表时间：
2016
影响因子：
4.6
通讯作者：
Steinmetz OM
中科院分区：
文献类型：
--
作者：
Krebs CF;Steinmetz OM
多项研究证实，CD4+T细胞是肾小球肾炎(GN)的中心角色。Th1和Th17反应的细胞会导致肾组织损伤，而Tregs则起到中介保护作用。最近，这些T细胞系之间的高度可塑性被提出。在炎症过程中，Th17细胞被证明具有转分化为Th1、Th2或抗炎TR1细胞的潜力。然而，目前来自GN研究的数据并没有表明Th17到Th1或Th2的相关转换，这使得Th17细胞的命运成为谜。另一方面，Tregs被推测为转分化为Th17细胞。同样，GN的数据也不支持这一概念。相反，似乎存在以前未被识别的亚专业效应器Treg谱系。这些细胞包括Th1特异性Treg1以及Th17诱导的Treg17细胞。此外，最近在肾小球肾炎中发现了一个双功能的Treg亚群，它分泌IL-17并与Th17特征转录因子RoRγt共同表达Foxp3。这些不同的高度专门化的效应因子Treg亚群与相应的T辅助效应细胞谱系之间的相似性可能导致了先前误解为Treg转分化。综上所述，Th17细胞在肾小球肾炎期间具有相对稳定的表型，而在Tregs的情况下，目前可用的数据表明谱系异质性而不是可塑性。
Multiple studies have identified CD4+ T cells as central players of glomerulonephritis (GN). Cells of the Th1 and Th17 responses cause renal tissue damage, while Tregs mediate protection. Recently, a high degree of plasticity among these T cell lineages was proposed. During inflammation, Th17 cells were shown to have the potential of transdifferentiation into Th1, Th2, or alternatively anti-inflammatory Tr1 cells. Currently available data from studies in GN, however, do not indicate relevant Th17 to Th1 or Th2 conversion, leaving the Th17 cell fate enigmatic. Tregs, on the other hand, were speculated to transdifferentiate into Th17 cells. Again, data from GN do not support this concept. Rather, it seems that previously unrecognized subspecialized effector Treg lineages exist. These include Th1 specific Treg1 as well as Th17 directed Treg17 cells. Furthermore, a bifunctional Treg subpopulation was recently identified in GN, which secrets IL-17 and coexpresses Foxp3 together with the Th17 characteristic transcription factor RORγt. Similarities between these different and highly specialized effector Treg subpopulations with the corresponding T helper effector cell lineages might have resulted in previous misinterpretation as Treg transdifferentiation. In summary, Th17 cells have a relatively stable phenotype during GN, while, in the case of Tregs, currently available data suggest lineage heterogeneity rather than plasticity.
登录
查看更多内容
影响因子：
46.9
作者：
Han, Arnold;Glanville, Jacob;Hansmann, Leo;Davis, Mark M.
通讯作者：
Davis, Mark M.
影响因子：
64.8
作者：
Esplugues, Enric;Huber, Samuel;Gagliani, Nicola;Hauser, Anja E.;Town, Terrence;Wan, Yisong Y.;O'Connor, William, Jr.;Rongvaux, Anthony;Van Rooijen, Nico;Haberman, Ann M.;Iwakura, Yoichiro;Kuchroo, Vijay K.;Kolls, Jay K.;Bluestone, Jeffrey A.;Herold, Kevan C.;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
影响因子：
32.4
作者：
Bailey-Bucktrout, Samantha L.;Martinez-Llordella, Marc;Zhou, Xuyu;Anthony, Bryan;Rosenthal, Wendy;Luche, Herve;Fehling, Hans J.;Bluestone, Jeffrey A.
通讯作者：
Bluestone, Jeffrey A.
影响因子：
64.5
作者：
Gaublomme JT;Yosef N;Lee Y;Gertner RS;Yang LV;Wu C;Pandolfi PP;Mak T;Satija R;Shalek AK;Kuchroo VK;Park H;Regev A
通讯作者：
Regev A
影响因子：
32.4
作者：
Huber S;Gagliani N;Esplugues E;O'Connor W Jr;Huber FJ;Chaudhry A;Kamanaka M;Kobayashi Y;Booth CJ;Rudensky AY;Roncarolo MG;Battaglia M;Flavell RA
通讯作者：
Flavell RA