Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner.
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DOI：
10.1016/j.immuni.2011.01.020
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发表时间：
2011-04-22
期刊：
影响因子：
32.4
通讯作者：
Flavell RA
中科院分区：
文献类型：
--
作者：
Huber S;Gagliani N;Esplugues E;O'Connor W Jr;Huber FJ;Chaudhry A;Kamanaka M;Kobayashi Y;Booth CJ;Rudensky AY;Roncarolo MG;Battaglia M;Flavell RA
辅助性T细胞17（Th 17）对于宿主防御细胞外微生物是重要的。然而，它们也涉及自身免疫性和慢性炎症性疾病，因此需要严格调控。体内直接控制定向致病性Th 17细胞的机制尚不清楚。我们在此发现，产生IL-17 A的CD 4 + T细胞在体内表达白细胞介素-10受体α（IL-10 R α）。重要的是，IL-10信号的T细胞特异性阻断导致小肠炎症期间IL-17 A +IFN-γ−（Th 17）和IL-17 A +IFN-γ+（Th 17 + Th 1）CD 4 + T细胞的选择性增加。CD 4 + Foxp 3 − IL-10产生（Tr 1）细胞和Foxp 3+调节（Treg）细胞能够在体内以IL-10依赖性方式控制Th 17和Th 17 + Th 1细胞。最后，IL-10治疗患有结肠炎的小鼠通过T细胞中的直接信号传导降低了Th 17和Th 17 + Th 1细胞的频率。因此，IL-10信号直接抑制Th 17和Th 17 + Th 1细胞。
T helper 17 (Th17) cells are important for host defense against extra-cellular microorganisms. However they are also implicated in autoimmune and chronic inflammatory diseases, and as such need to be tightly regulated. The mechanisms that directly control committed pathogenic Th17 cells in vivo remain unclear. We showed here that IL-17A-producing CD4+ T cells expressed interleukin-10 receptor α (IL-10Rα) in vivo. Importantly, T cell specific blockade of IL-10 signaling led to a selective increase of IL-17A+IFN-γ− (Th17), and IL-17A+IFN-γ+ (Th17+Th1) CD4+ T cells during intestinal inflammation in the small intestine. CD4+ Foxp3− IL-10 producing (Tr1) cells and Foxp3+ regulatory (Treg) were able to control Th17 and Th17+Th1 cells in an IL-10-dependent manner in vivo. Lastly, IL-10 treatment of mice with established colitis decreased Th17 and Th17+Th1 cells frequencies via direct signaling in T cells. Thus IL-10 signaling directly suppresses Th17 and Th17+Th1 cells.
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影响因子：
30.5
作者：
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
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影响因子：
5.4
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Gu, Yongpeng;Yang, Jianfei;Ouyang, Xinshou;Liu, Weicheng;Li, Hongxing;Yang, Jianjun;Bromberg, Jonathan;Chen, Shu-Hsia;Mayer, Lloyd;Unkeless, Jay C.;Xiong, Huabao
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Xiong, Huabao
影响因子：
32.4
作者：
Kamanaka, Masahito;Kim, Sean T.;Flavell, Richard A.
通讯作者：
Flavell, Richard A.
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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Romagnani S