Effects of age and ethanol on DNA single-strand breaks and toxicity induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or n-nitrosodimethylamine in hamster and rat liver.
Effects of age and ethanol on DNA single-strand breaks and toxicity induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone or n-nitrosodimethylamine in hamster and rat liver.
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年龄和乙醇对仓鼠和大鼠肝脏中 4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁酮或正亚硝基二甲胺诱导的 DNA 单链断裂和毒性的影响。
DOI：
10.1016/0304-3835(93)90240-a
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发表时间：
1993
期刊：
影响因子：
9.7
通讯作者：
Schuller,HM
中科院分区：
文献类型：
--
作者：
Jorquera,R;Castonguay,A;Schuller,HM
研究了年龄和酒精暴露对单次等摩尔剂量(0.39mmo.kgNNK)或N-亚硝基二甲基胺(4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone，NDMA)诱发的金黄地鼠和大鼠肝脏DNA单链断裂和肝细胞损伤的影响。在成年仓鼠和大鼠的肝脏中，NNK诱导的DNA SSB比NDMA多10-50%，但在新生动物中没有观察到类似的差异。比较了亚硝胺对新生动物和成年动物肝脏DNA的损伤。新生仓鼠对NNK诱导的DNA损伤的敏感性低于成年仓鼠，而新生大鼠对NDMA诱导的DNA损伤比成年大鼠更敏感。与新生仓鼠和大鼠相比，宫内乙醇暴露对NNK或NDMA诱导的肝脏DNA SSB没有显著影响。有趣的是，在酒精消费的成年仓鼠和大鼠中，观察到NNK诱导的肝脏DNA SSB的程度和毒性的物种差异。乙醇处理使金黄地鼠肝DNA单链断裂频率显著降低(35%)，NNK诱导的肝毒性增加3.5倍。
The effects of age and ethanol exposure on liver DNA single-strand breaks (SSB) and liver cell injury induced in hamsters and rats by a single equimolar dose (0.39 mmol/kg) of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) orN-nitrosodimethylamine (NDMA) were investigated. NNK induced more DNA SSB (by 10–50%) than NDMA in the liver of adult hamsters and rats, but similar differences were not observed in newborn animals. Nitrosamine-induced hepatic DNA damages was compared in newborn and adult animals. While newborn hamsters were less sensitive to NNK-induced DNA damage than adult hamsters, newborn rats were more sensitive to NDMA-induced DNA damage than adult rats. In utero ethanol exposure did not alter significantly the induction of hepatic DNA SSB by NNK or NDMA compared to newborn hamsters and rats. Interestingly, species differences in the extents of NNK-induced hepatic DNA SSB and toxicity were observed in ethanol-consuming adult hamsters and rats. Ethanol treatment of hamsters caused a significant reduction (by 35%) of the frequency of hepatic DNA SSB and a 3.5-fold enhancement of hepatotoxicity induced by NNK.
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作者：
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作者：
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Hecht,SS
DOI：
--
发表时间：
1991
期刊：
IARC scientific publications
影响因子：
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作者：
Yang,CS;Smith,T;Ishizaki,H;Hong,JY
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DOI：
10.1016/s0006-291x(88)80731-9
发表时间：
1988
影响因子：
3.1
作者：
Mufti,SI;Salvagnini,M;Lieber,CS;Garro,AJ
通讯作者：
Garro,AJ