Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma.
Intraperitoneal photodynamic therapy mediated by a fullerene in a mouse model of abdominal dissemination of colon adenocarcinoma.
复制标题
DOI：
10.1016/j.nano.2011.04.007
复制
发表时间：
2011-12
影响因子：
5.4
通讯作者：
Hamblin, Michael R.
中科院分区：
文献类型：
--
作者：
Mroz, Pawel;Xia, Yumin;Asanuma, Daisuke;Konopko, Aaron;Zhiyentayev, Timur;Huang, Ying-Ying;Sharma, Sulbha K.;Dai, Tianhong;Khan, Usman J.;Wharton, Tim;Hamblin, Michael R.
关键词：
Functionalized fullerenes represent a new class of photosensitizer (PS) that is being investigated for photodynamic therapy (PDT) of various diseases including cancer. We tested the hypothesis that fullerenes could be used to mediate PDT of intraperitoneal (IP) carcinomatosis in a mouse model. In humans this form of cancer responds poorly to standard treatment and manifests as a thin covering of tumor nodules on intestines, and other abdominal organs. We used a colon adenocarcinoma cell line (CT26) stably expressing luciferase to allow monitoring of IP tumor burden in BALB/c mice by non-invasive real-time optical imaging using a sensitive low light camera. IP injection of a preparation of N-methylpyrrolidinium-fullerene formulated in Cremophor-EL micelles, followed by white-light illumination delivered through the peritoneal wall (after creation of a skin flap) produced a statistically significant reduction in bioluminescence and a survival advantage in mice.
登录
查看更多内容
影响因子：
--
作者：
Cengel, K A;Glatstein, E;Hahn, S M
通讯作者：
Hahn, S M
DOI：
10.1016/j.jphotobiol.2009.11.010
发表时间：
2010-01-21
影响因子：
5.4
作者：
Kato, Shinya;Aoshima, Hisae;Miwa, Nobuhiko
通讯作者：
Miwa, Nobuhiko
影响因子：
3.7
作者：
Canter, RJ;Mick, R;Fraker, DL
通讯作者：
Fraker, DL
影响因子：
3.9
作者：
MARTIN, JP;LOGSDON, N
通讯作者：
LOGSDON, N
DOI：
10.2217/nnm.10.98
发表时间：
2010-12
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Lu Z;Dai T;Huang L;Kurup DB;Tegos GP;Jahnke A;Wharton T;Hamblin MR
通讯作者：
Hamblin MR