Parental intermittent claudication as risk factor for claudication in adults.
Parental intermittent claudication as risk factor for claudication in adults.
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DOI：
10.1016/j.amjcard.2011.10.032
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发表时间：
2012-03-01
影响因子：
2.8
通讯作者：
Murabito, Joanne M.
中科院分区：
文献类型：
--
作者：
Prushik, Scott G.;Farber, Alik;Gona, Philimon;Shrader, Peter;Pencina, Michael J.;D'Agostino, Ralph B., Sr.;Murabito, Joanne M.
关于间歇性跛行 (IC) 的家族聚集性，人们知之甚少。我们的目的是检查父母 IC 是否会增加成年后代的 IC 风险，而与已确定的心血管危险因素无关。我们对弗雷明汉心脏研究 (FHS) 的后代队列参与者进行了评估，这些参与者年龄为 30 岁或以上，无心血管疾病 (CVD)，并且父母双方都参加了 FHS（n = 2970 名独特参与者，其中 53% 为女性）。汇总比例风险回归用于检查后代参与者 12 年发生 IC 的风险是否与父母根据年龄、性别、糖尿病、吸烟、收缩压、总胆固醇、高密度脂蛋白 (HDL) 胆固醇、抗高血压和脂质治疗进行调整后的 IC 相关。在父母 IC 历史组的 909 人检查和无父母 IC 历史组的 5397 人检查中，随访期间发生了 101 起 IC 事件（29 人有父母 IC 历史，72 人无父母 IC 历史）。在有或没有父母 IC 病史的参与者中，年龄和性别调整后的 12 年累积发病率每 1000 人年分别为 5.08 (95% CI: 2.74; 7.33) 和 2.34 (95% CI: 1.46; 3.19)。父母 IC 病史显着增加后代发生 IC 的风险（多变量调整风险比为 1.81，95% CI 1.14，2.88）。对 CVD 发生进行调整后，风险比没有变化（1.83，95% CI 1.15，2.91）。总之，父母的 IC 会增加成年后代的 IC 风险，与已确定的风险因素无关。这些数据表明外周动脉疾病的遗传因素，并支持未来对遗传原因的研究。
Little is known about the familial aggregation of intermittent claudication (IC). Our objective was to examine whether parental IC increased adult offspring risk of IC independent of established cardiovascular risk factors. We evaluated Offspring cohort participants of the Framingham Heart Study (FHS) who were 30 years or older, cardiovascular disease (CVD) free, and had both parents enrolled in the FHS (n= 2970 unique participants, 53% women). Pooled proportional hazards regression was used to examine whether the 12 year risk for incident IC in offspring participants was associated with parental IC adjusting for age, sex, diabetes, smoking, systolic blood pressure, total cholesterol, high density lipoprotein (HDL) cholesterol, anti-hypertensive and lipid treatment. Among 909 person-exams in the parental IC history group and 5397 person-exams in the no parental IC history group there were 101 incident IC events (29 with parental IC history, 72 without parental IC history) during follow-up. Age and sex adjusted 12-year cumulative incidence rates per 1000 person-years were 5.08 (95% CI: 2.74; 7.33) and 2.34 (95% CI: 1.46; 3.19) in participants with and without parental IC history. Parental history of IC significantly increased the risk of incident IC in offspring (multivariable adjusted hazard ratio of 1.81, 95% CI 1.14, 2.88). The hazard ratio was unchanged with adjustment for occurrence of CVD (1.83, 95% CI 1.15, 2.91). In conclusion, IC in parents increases risk for IC in adult offspring independent of established risk factors. These data suggest a genetic component of peripheral artery disease and support future research into genetic causes.
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影响因子：
2
作者：
Pencina, Michael J.;D'Agostino, Ralph B., Sr.;Steyerberg, Ewout W.
通讯作者：
Steyerberg, Ewout W.
影响因子：
39.2
作者：
Berg, Alfred O.;Baird, Macaran A.;Williams, Janet K.
通讯作者：
Williams, Janet K.
影响因子：
120.7
作者：
Lloyd-Jones, DM;Nam, BH;O'Donnell, CJ
通讯作者：
O'Donnell, CJ
影响因子：
30.8
作者：
Helgadottir, Anna;Thorleifsson, Gudmar;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
11.1
作者：
Bjorck, H. M.;Lanne, T.;Eriksson, P.
通讯作者：
Eriksson, P.