Optogenetic probes.

Optogenetic probes.
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光遗传学探针。

DOI:
10.1007/s11068-008-9037-4
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发表时间:
2008
期刊:
Brain cell biology
影响因子:
--
通讯作者:
Augustine,GeorgeJ
Augustine,GeorgeJ
中科院分区:
--
文献类型:
--
作者:
Yasuda,Ryohei;Augustine,GeorgeJ

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我们欢迎您来到我们的《脑细胞生物学》特刊。这期特刊的主题是神经功能和电路的光遗传学探测,旨在为我们的读者提供当代神经科学最令人兴奋的领域之一的进展报告。该领域的目标是开发和应用控制或检测神经元活动的光学探测器。光学技术使得以较高的时空分辨率和相对非侵入性的方式实现这些目标成为可能。通过对这些探针进行基因编码,可以获得针对这些探针的高度特异性,这样现在就有可能检查特定突触和神经元的功能,并确定它们对大脑电路的贡献。正如你从本期特刊收集的文章中所看到的那样,这些新的光基因技术允许进行许多类型的实验,这些实验在几年前还是不可想象的,并且已经为有关大脑工作的基本问题提供了答案。在这一期中,我们介绍了这一领域许多领导者的文章。第一组文章描述了开发细胞内信号的光遗传指示器的最新技术:
We welcome you to our special issue of Brain Cell Biology. The theme of this special issue, Optogenetic probes of neuronal function and circuitry, is intended to provide our readers with a progress report on one of the most exciting areas of contemporary Neuroscience. The goals of this field are to develop and to apply optical probes that either control or detect neuronal activity. Optical techniques make it possible to achieve these goals with high spatiotemporal resolution and in a relatively non-invasive manner. By making these probes genetically encoded, it is possible to obtain great specificity in targeting these probes, so that it is now possible to examine the function of specific synapses and neurons and to determine their contributions to brain circuitry. As you can see from the articles collected in this special issue, these new optogenetic technologies permit many types of experiments that would have been unimaginable only a few years ago and already are providing answers to fundamental questions about the workings of the brain. In this issue we present articles from many of the leaders in this field. The first group of articles describes the state of the art in developing optogenetic indicators of intracellular signaling:
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