Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966.
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966.
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DOI：
10.1371/journal.pone.0099133
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Blakemore AI
中科院分区：
文献类型：
--
作者：
Buxton JL;Das S;Rodriguez A;Kaakinen M;Couto Alves A;Sebert S;Millwood IY;Laitinen J;O'Reilly PF;Jarvelin MR;Blakemore AI
关于白细胞端粒长度（LTL）和肥胖的研究产生了相互矛盾的结果，并且终生体重指数（BMI）和端粒长度之间的关系仍不清楚。因此，我们测试了 5,598 名参与者测量的成人 LTL 与以下因素之间的关联： i) 儿童生长指标（BMI 和肥胖反弹年龄 (AR)）； ii) 从儿童期到成年期 BMI 的变化，以及 iii) 成人 BMI、腰臀比 (WHR)、身体肥胖指数 (BAI)。女性 AR 时的儿童期 BMI 与 31 岁时的 LTL 呈正相关（P = 0.041）。男性（分别为 P = 0.025 和 P = 0.049）和女性（P = 0.029 和 P = 0.008）的成年 BMI 和 WHR，以及女性 BAI（P = 0.021）与 31 岁时的 LTL 呈负相关。幼儿期至成年期标准化体重指数的增加与女性成年期寿命缩短相关（P = 0.008）。我们发现，LTL 与男性和女性的多种肥胖指标呈负相关。此外，女性从童年到成年的 BMI 增加与 31 岁时端粒变短有关，这可能表明生物衰老加速。
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing.
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影响因子：
3.7
作者：
Farzaneh-Far R;Lin J;Epel E;Lapham K;Blackburn E;Whooley MA
通讯作者：
Whooley MA
影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
影响因子：
4.5
作者：
Nordfjall, Katarina;Svenson, Ulrika;Norrback, Karl-Fredrik;Adolfsson, Rolf;Lenner, Per;Roos, Goran
通讯作者：
Roos, Goran
影响因子：
6.9
作者：
Bergman, Richard N.;Stefanovski, Darko;Buchanan, Thomas A.;Sumner, Anne E.;Reynolds, James C.;Sebring, Nancy G.;Xiang, Anny H.;Watanabe, Richard M.
通讯作者：
Watanabe, Richard M.
影响因子：
14.9
作者：
Cawthon RM
通讯作者：
Cawthon RM