Telomere length and early severe social deprivation: linking early adversity and cellular aging.
Telomere length and early severe social deprivation: linking early adversity and cellular aging.
复制标题
DOI：
10.1038/mp.2011.53
复制
发表时间：
2012-07
影响因子：
11
通讯作者：
Nelson CA
中科院分区：
文献类型：
--
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
在成人中，端粒长度的加速磨损与心理压力和早期逆境有关；然而，还没有研究检验童年时期的端粒长度是否与早期经历有关。布加勒斯特早期干预项目是一项独特的寄养安置与机构持续护理比较的随机对照试验。作为研究设计的结果，参与者接触到了一段量化的机构护理时间范围，并代表了一个理想的人群，在其中检查特定的早期逆境、机构护理和端粒长度之间的关联。我们研究了平均相对端粒长度、端粒重复拷贝数与单基因拷贝数(T/S)的比率与接受机构护理的关系，机构护理以基线(平均年龄22个月)和54个月大的儿童在机构生活的时间百分比来量化。T/S比值与发病时间百分比呈显著负相关。在儿童期中期，接受机构护理的儿童相对端粒长度明显较短。性别对这一主效应有修正作用。女性在机构看护的时间百分比显著预测端粒长度，而54个月的机构看护时间百分比对男性端粒长度有很强的预测作用。这是第一次证明端粒长度与制度化之间的联系，第一次发现儿童的逆境与端粒长度之间的联系，并为日益增长的将端粒长度与早期逆境联系起来的文献做出了贡献。
Accelerated telomere length attrition has been associated with psychological stress and early adversity in adults; however, no studies have examined whether telomere length in childhood is associated with early experiences. The Bucharest Early Intervention Project is a unique randomized controlled trial of foster care placement compared with continued care in institutions. As a result of the study design, participants were exposed to a quantified range of time in institutional care, and represented an ideal population in which to examine the association between a specific early adversity, institutional care and telomere length. We examined the association between average relative telomere length, telomere repeat copy number to single gene copy number (T/S) ratio and exposure to institutional care quantified as the percent of time at baseline (mean age 22 months) and at 54 months of age that each child lived in the institution. A significant negative correlation between T/S ratio and percentage of time was observed. Children with greater exposure to institutional care had significantly shorter relative telomere length in middle childhood. Gender modified this main effect. The percentage of time in institutional care at baseline significantly predicted telomere length in females, whereas the percentage of institutional care at 54 months was strongly predictive of telomere length in males. This is the first study to demonstrate an association between telomere length and institutionalization, the first study to find an association between adversity and telomere length in children, and contributes to the growing literature linking telomere length and early adversity.
登录
查看更多内容
DOI：
10.1002/ajpa.10183
发表时间：
2002-01-01
期刊：
YEARBOOK OF PHYSICAL ANTHROPOLOGY, VOL 45
影响因子：
--
作者：
Cameron, N;Demerath, EW
通讯作者：
Demerath, EW
DOI：
10.1111/j.1469-7610.2010.02249.x
发表时间：
2010-07-01
影响因子：
7.6
作者：
Kumsta, Robert;Stevens, Suzanne;Sonuga-Barke, Edmund J. S.
通讯作者：
Sonuga-Barke, Edmund J. S.
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
DOI：
10.1111/j.1601-183x.2010.00588.x
发表时间：
2010-08
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Kinnally EL;Capitanio JP;Leibel R;Deng L;LeDuc C;Haghighi F;Mann JJ
通讯作者：
Mann JJ
影响因子：
5
作者：
Fitzpatrick, Annette L.;Kronmal, Richard A.;Aviv, Abraham
通讯作者：
Aviv, Abraham