Ruminococcus gnavus: friend or foe for human health.
Ruminococcus gnavus: friend or foe for human health.
复制标题
DOI：
10.1093/femsre/fuad014
复制
发表时间：
2023-03-10
影响因子：
11.3
通讯作者：
中科院分区：
文献类型：
--
作者：
活泼反刍球菌于1974年首次被确定为健康个体肠道中的严格厌氧菌，几十年来，其研究仅限于特定的酶或细菌素。随着宏基因组学的出现，R. gnavus与越来越多的肠和肠外疾病（从炎症性肠病到神经障碍）正相关和负相关。这引起了人们对了解R.以及影响其与健康和疾病相关性的分子介质。从约250篇文献引用R.自1990年以来，94%是在过去10年内发表的。本文综述了近年来国内外对该菌生物学特性的研究进展。gnavus，它在婴儿和成人肠道微生物群中的发生以及影响其在胃肠道定植的因素;我们还讨论了我们对其在宿主健康和疾病中的作用的认识的现状。我们强调知识的差距和讨论的假设，不同的健康结果与R。肠道中的gavus是菌株和生态位特异性的。 侏儒瘤胃球菌是婴儿和成人肠道菌群中的一个普遍成员，已成为健康和疾病的关键生物标志物，具有功能特征的免疫和代谢特性。
Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extraintestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterization of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonization of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific. Ruminoccocus gnavus, a prevalent member of the infant and adult gut microbiota has emerged a as a key biomarker of health and diseases with functionally characterized immune and metabolic properties.
登录
查看更多内容
影响因子：
24.5
作者：
Cani PD
通讯作者：
Cani PD
影响因子：
8.2
作者：
Allin KH;Tremaroli V;Caesar R;Jensen BAH;Damgaard MTF;Bahl MI;Licht TR;Hansen TH;Nielsen T;Dantoft TM;Linneberg A;Jørgensen T;Vestergaard H;Kristiansen K;Franks PW;IMI-DIRECT consortium;Hansen T;Bäckhed F;Pedersen O
通讯作者：
Pedersen O
影响因子：
4.5
作者：
Bordugo A;Salvetti E;Rodella G;Piazza M;Dianin A;Amoruso A;Piacentini G;Pane M;Torriani S;Vitulo N;Felis GE
通讯作者：
Felis GE
影响因子：
4.6
作者：
Angel Pascual-Itoiz, Miguel;Pena-Cearra, Ainize;Abecia, Leticia
通讯作者：
Abecia, Leticia
影响因子：
4.6
作者：
Biernat, Kristen A.;Pellock, Samuel J.;Redinbo, Matthew R.
通讯作者：
Redinbo, Matthew R.