The ages of anxiety--differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder.
The ages of anxiety--differences across the lifespan in the default mode network functional connectivity in generalized anxiety disorder.
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DOI：
10.1002/gps.4051
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发表时间：
2014-07
影响因子：
4
通讯作者：
Aizenstein, Howard
中科院分区：
文献类型：
--
作者：
Andreescu, Carmen;Sheu, Lei K.;Tudorascu, Dana;Walker, Sarah;Aizenstein, Howard
关键词：
广泛性焦虑障碍是最常见的焦虑障碍之一，但其神经基础研究相对较少。本研究旨在描述广泛性焦虑障碍（GAD）患者默认模式网络（DMN）在整个生命周期中的功能连通性。在受试者休息时收集功能和结构MRI数据。我们分析了27名广泛性焦虑症参与者和39名非焦虑对照组参与者的DMN静息状态功能连接模式。使用双向方差分析，我们探讨了年龄和广泛性焦虑症状态对功能连接的相互作用。在广泛性焦虑症参与者中，我们分析了功能连接指数与疾病持续时间和担忧严重程度的相关性。年龄-焦虑的相互作用表明，相对于年轻的参与者，老年人对后扣带种子和内侧前额叶皮层之间的功能连接有更大的焦虑影响。患病时间越长，后扣带皮层和脑岛之间的功能连接越强。担忧严重程度与PCC种子和内侧前额叶皮层之间的功能连通性呈负相关。广泛性焦虑症的存在、疾病持续时间的延长和更严重的担忧加剧了年龄对默认模式网络功能连通性的影响。这些结果支持对晚年焦虑进行量身定制的研究和干预的必要性。
Generalized Anxiety Disorder is one of the most prevalent anxiety disorders, but its neural basis is relatively understudied. This study aims to characterize the functional connectivity in the Default Mode Network (DMN) in Generalized Anxiety Disorder (GAD) across the lifespan. Functional and structural MRI data were collected with subjects at rest. We analyzed the resting state functional connectivity patterns in the DMN for twenty-seven GAD participants and thirty-nine non-anxious comparison participants. Using a two-way ANOVA, we explored the interaction between age and GAD status on functional connectivity. In GAD participants we analyzed the correlation of functional connectivity indices with the duration of illness and worry severity. The age-by-anxiety interaction showed a greater anxiety effect on the functional connectivity between the posterior cingulate seed and the medial prefrontal cortex for the older group relative to the younger participants. Longer duration of illness was positively correlated with greater functional connectivity between the posterior cingulate cortex and the insula. Worry severity was inversely correlated with the functional connectivity between the PCC seed and the medial prefrontal cortex. The presence of GAD, longer duration of illness and more severe worry exacerbate the effects of age on the functional connectivity in the Default Mode Network. These results support the need for tailored research and interventions in late-life anxiety.
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DOI：
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