Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.
Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.
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人类细胞中 Scc3 同源物 SA1 和 SA2 分别对端粒和着丝粒凝聚力进行差异调节。
DOI：
10.1083/jcb.200903096
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发表时间：
2009-10-19
期刊：
影响因子：
--
通讯作者：
Smith S
中科院分区：
文献类型：
--
作者：
Canudas S;Smith S
In vertebrates, two Scc3 homologues control sister chromatid cohesion of distinct chromosomal regions. Replicated sister chromatids are held together until mitosis by cohesin, a conserved multisubunit complex comprised of Smc1, Smc3, Scc1, and Scc3, which in vertebrate cells exists as two closely related homologues (SA1 and SA2). Here, we show that cohesinSA1 and cohesinSA2 are differentially required for telomere and centromere cohesion, respectively. Cells deficient in SA1 are unable to establish or maintain cohesion between sister telomeres after DNA replication in S phase. The same phenotype is observed upon depletion of the telomeric protein TIN2. In contrast, in SA2-depleted cells telomere cohesion is normal, but centromere cohesion is prematurely lost. We demonstrate that loss of telomere cohesion has dramatic consequences on chromosome morphology and function. In the absence of sister telomere cohesion, cells are unable to repair chromatid breaks and suffer sister telomere loss. Our studies elucidate the functional distinction between the Scc3 homologues in human cells and further reveal an essential role for sister telomere cohesion in genomic integrity.
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DOI：
10.1083/jcb.151.4.749
发表时间：
2000-11-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Sumara I;Vorlaufer E;Gieffers C;Peters BH;Peters JM
通讯作者：
Peters JM
DOI：
10.1083/jcb.200111002
发表时间：
2002-02-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Anderson DE;Losada A;Erickson HP;Hirano T
通讯作者：
Hirano T
影响因子：
9.8
作者：
McGuinness BE;Hirota T;Kudo NR;Peters JM;Nasmyth K
通讯作者：
Nasmyth K
影响因子：
16
作者：
Haering, CH;Löwe, J;Nasmyth, K
通讯作者：
Nasmyth, K
影响因子：
10.5
作者：
Chang, CR;Wu, CS;Gartenberg, MR
通讯作者：
Gartenberg, MR