Vitamin C levels amongst initial survivors of out of hospital cardiac arrest.
Vitamin C levels amongst initial survivors of out of hospital cardiac arrest.
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DOI：
10.1016/j.resuscitation.2020.09.005
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发表时间：
2020-11
期刊：
影响因子：
6.5
通讯作者：
Moskowitz A
中科院分区：
文献类型：
--
作者：
Gardner R;Liu X;Wang Y;Cole A;Heydrick S;Donnino MW;Moskowitz A
维生素C缺乏已被描述为败血症患者。心脏骤停后综合征与败血症有相似之处，然而，骤停后患者的维生素C水平尚未完全表征。我们评估了被捕后人群的维生素C水平。这是一项在三级保健中心进行的回顾性观察性研究。从先前的研究中选择了骤停后、败血症和健康对照患者作为方便的样本。从急诊室入院6小时内获得的样本中测量维生素C水平。一部分心脏骤停患者在24小时后额外测量维生素C水平。共纳入84例患者（34例健康对照，25例停搏后患者，25例败血症患者）。心脏骤停患者的基线维生素C水平中位数为0.33 mg/dL(0.05-0.83)，而健康对照组为0.91mg/dL (0.69-1.48) (p<0.01)，脓毒症组为0.28 mg/dL (0.11-0.59) （p=0.36）。心脏骤停患者的维生素C水平在两个时间点之间下降，但变化无统计学意义（中位数下降0.26 mg/dL, p=0.08）。与对照组相比，骤停后患者的血清维生素C水平较低，与败血症患者相似。未来对心脏骤停后维生素C水平和补充的研究可能是有必要的。
Vitamin C deficiency has been described in patients with sepsis. The post-cardiac arrest syndrome shares similarities to sepsis, however vitamin C levels in post-arrest patients have been incompletely characterized. We assessed vitamin C levels in a post-arrest population. This was a retrospective observational study at a tertiary care center. A convenience sample of post-arrest, sepsis, and healthy control patients was selected from prior studies. Vitamin C levels were measured from samples obtained within 6-hours of emergency department admission. A subset of cardiac arrest patients had vitamin C levels additionally measured at 24-hours later. A total of 84 patients (34 healthy controls, 25 post-arrest, and 25 septic patients) were included. The median baseline vitamin C level in cardiac arrest patients was 0.33 mg/dL (0.05–0.83), as compared to 0.91mg/dL (0.69–1.48) in the healthy control group (p<0.01) and 0.28 mg/dL (0.11–0.59) in the septic group (p=0.36). Vitamin C levels for cardiac arrest patients fell between the two time points, but the change was not statistically significant (median decrease 0.26 mg/dL, p=0.08). Serum vitamin C levels were lower in post-arrest patients compared to controls and were similar to patients with sepsis. Future studies of vitamin C levels and supplementation following cardiac arrest may be warranted.
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DOI：
10.1186/s13054-015-1131-2
发表时间：
2015-11-27
期刊：
Critical care (London, England)
影响因子：
--
作者：
Carr AC;Shaw GM;Fowler AA;Natarajan R
通讯作者：
Natarajan R
影响因子：
2.2
作者：
Long, CL;Maull, KI;Sauberlich, HE
通讯作者：
Sauberlich, HE
影响因子：
37.8
作者：
Adrie, C;Adib-Conquy, M;Cavaillon, JM
通讯作者：
Cavaillon, JM
影响因子：
6.5
作者：
Donnino, Michael W.;Liu, Xiaowen;Callaway, Clifton W.
通讯作者：
Callaway, Clifton W.
影响因子：
120.7
作者：
Fowler, Alpha A., III;Truwit, Jonathon D.;Halquist, Matthew
通讯作者：
Halquist, Matthew